Current status of resistance to ivermectin in Rhipicephalus sanguineus sensu stricto infesting dogs in three provinces in Argentina.

Autor: Daniele MR; Universidad Nacional de Río Negro, Sede Alto Valle y Valle Medio, Escuela de Veterinaria y Producción Agroindustrial, Choele Choel, Rio Negro 8360, Argentina; Cátedra de Farmacología Especial y Toxicología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118s/n, CC 296, La Plata 1900, Argentina; Cátedra de Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste, Sargento Cabral 2139, Corrientes 3400, Argentina., Dadé MM; Universidad Nacional de Río Negro, Sede Alto Valle y Valle Medio, Escuela de Veterinaria y Producción Agroindustrial, Choele Choel, Rio Negro 8360, Argentina; Cátedra de Farmacología Especial y Toxicología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118s/n, CC 296, La Plata 1900, Argentina; Cátedra de Farmacología Básica, Facultad de Ciencias Médicas de la Universidad Nacional de La Plata, Laboratorio de Artrópodos y Vectores (LabArVec), 60 y 120 s/n, La Plata 1900, Argentina., Álvarez JD; Cátedra de Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste, Sargento Cabral 2139, Corrientes 3400, Argentina., Reynaldi FJ; CCT CONICET La Plata, LAVIR (Laboratorio de Virología), Facultad de Veterinaria, Universidad Nacional de La Plata, 60 y 118s/n, La Plata 1900, Argentina., Errecalde JO; Cátedra de Farmacología Especial y Toxicología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118s/n, CC 296, La Plata 1900, Argentina; Cátedra de Farmacología Básica, Facultad de Ciencias Médicas de la Universidad Nacional de La Plata, Laboratorio de Artrópodos y Vectores (LabArVec), 60 y 120 s/n, La Plata 1900, Argentina., Rodríguez-Vivas RI; Campus de Ciencias Biológicas y Agropecuarias, Facultad de Medicina Veterinaria y Zootecnia de la Universidad Autónoma de Yucatán, Km 15.5 Carretera Mérida-Xmatkuil, Mérida, Yucatán, Mexico. Electronic address: rvivas@correo.uady.mx.
Jazyk: angličtina
Zdroj: Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2021 Dec; Vol. 26, pp. 100624. Date of Electronic Publication: 2021 Aug 28.
DOI: 10.1016/j.vprsr.2021.100624
Abstrakt: Intensive use of macrocyclic lactones for parasite control exerts strong selective pressure for arthropods such as ticks to become resistant to them. Rhipicephalus sanguineus sensu stricto is a tick and disease vector of significant public health and veterinary importance worldwide. We assessed the toxicological response to the macrocyclic lactone ivermectin (IVM) in R. sanguineus s.s. infesting dogs in Argentina. Samples of nine tick populations were obtained by inspecting dogs at veterinary clinics, hospitals, or rural areas in the provinces of San Luis, Rio Negro, and Buenos Aires. Pet owners were interviewed to gather data on the history of dog treatment with ectoparasiticides. The larval immersion test was used to assess the toxicological response of R. sanguineus s.s. to IVM. Dose-response mortality regressions, lethal concentrations (LC), and slope were calculated by probit analysis. The lowest LC concentrations were used to designate the reference susceptible population because a laboratory reference strain of R. sanguineus s.s. does not exist in Argentina. Compared with the most susceptible tick population in this study, six populations (66.66%) were classified as resistant to IVM. A clear interpopulation variation in the level of IVM resistance was present (resistance ratios at LC 50% ranged from 1.0 to 18.33 and at LC 99% ranged from 1.0 to 8.96). In San Luis Province, all tick populations were classified as resistant. The highest level of IVM resistance (resistance ratio at LC 50% :18.83 and LC 99% :8.96) was found in a population of R. sanguineus s.s. from a rural area in the province of Buenos Aires. It is concluded that populations of R. sanguineus s.s. from dogs in three provinces of Argentina were resistant to IVM. Clear interpopulation variation in the level of IVM resistance was present.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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