Progression to pseudomyxoma peritonei in patients with low grade appendiceal mucinous neoplasms discovered at time of appendectomy.

Autor: Reiter S; Department of Surgery, Division of Surgical Oncology, Swedish Medical Center, 747 Broadway, Heath 10, Suite 1003, Seattle, WA, 98122, USA. Electronic address: shelby.reiter@swedish.org., Rog CJ; Department of Surgery, Division of Surgical Oncology, Swedish Medical Center, 747 Broadway, Heath 10, Suite 1003, Seattle, WA, 98122, USA. Electronic address: colin.rog@swedish.org., Alassas M; Department of Surgery, Division of Surgical Oncology, Swedish Medical Center, 747 Broadway, Heath 10, Suite 1003, Seattle, WA, 98122, USA. Electronic address: mohamed.alassas@swedish.org., Ong E; Department of Surgery, Division of Surgical Oncology, Swedish Medical Center, 747 Broadway, Heath 10, Suite 1003, Seattle, WA, 98122, USA. Electronic address: evan.ong@swedish.org.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2022 Jun; Vol. 223 (6), pp. 1183-1186. Date of Electronic Publication: 2021 Dec 03.
DOI: 10.1016/j.amjsurg.2021.12.003
Abstrakt: Background: The discovery of a low grade appendiceal mucinous neoplasm (LAMN) during appendectomy is a rare scenario. These neoplasms can progress to pseudomyxoma peritonei (PMP), however the incidence of progression is not well known.
Methods: The records of all patients with a diagnosis of localized LAMN found during appendectomy were identified, and demographic, tumor, surveillance, and outcome variables were analyzed.
Results: Progression to PMP occurred in 20% of patients in an average of 12.4 months after appendectomy with median follow-up of 18 months. Tumor variables such as margin positivity, appendiceal perforation, and presence of extra-appendiceal acellular mucin or mucinous epithelium on the serosal were not significantly associated with progression.
Conclusions: During an average follow-up period of 18 months after surgery, progression to PMP occurred in a fifth of patients. It is difficult to predict which patients will progress, therefore cross-sectional imaging surveillance is recommended for all patients.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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