Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study.

Autor: Corrêa TD; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Midega TD; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Timenetsky KT; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Cordioli RL; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Barbas CSV; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Silva Júnior M; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Bravim BA; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Silva BC; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Matos GFJ; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Nawa RK; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Carvalho FRT; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Queiroz VNF; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Rabello Filho R; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Piza FMT; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Pereira AJ; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Pesavento ML; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Eid RAC; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Santos BFCD; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Pardini A; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Teich VD; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Laselva CR; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Cendoroglo Neto M; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Klajner S; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Ferraz LJR; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Jazyk: English; Portuguese
Zdroj: Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2021 Dec 03; Vol. 19, pp. eAO6739. Date of Electronic Publication: 2021 Dec 03 (Print Publication: 2021).
DOI: 10.31744/einstein_journal/2021AO6739
Abstrakt: Objective: To describe clinical characteristics, resource use, outcomes, and to identify predictors of in-hospital mortality of patients with COVID-19 admitted to the intensive care unit.
Methods: Retrospective single-center cohort study conducted at a private hospital in São Paulo (SP), Brazil. All consecutive adult (≥18 years) patients admitted to the intensive care unit, between March 4, 2020 and February 28, 2021 were included in this study. Patients were categorized between survivors and non-survivors according to hospital discharge.
Results: During the study period, 1,296 patients [median (interquartile range) age: 66 (53-77) years] with COVID-19 were admitted to the intensive care unit. Out of those, 170 (13.6%) died at hospital (non-survivors) and 1,078 (86.4%) were discharged (survivors). Compared to survivors, non-survivors were older [80 (70-88) versus 63 (50-74) years; p<0.001], had a higher Simplified Acute Physiology Score 3 [59 (54-66) versus 47 (42-53) points; p<0.001], and presented comorbidities more frequently. During the intensive care unit stay, 56.6% of patients received noninvasive ventilation, 32.9% received mechanical ventilation, 31.3% used high flow nasal cannula, 11.7% received renal replacement therapy, and 1.5% used extracorporeal membrane oxygenation. Independent predictors of in-hospital mortality included age, Sequential Organ Failure Assessment score, Charlson Comorbidity Index, need for mechanical ventilation, high flow nasal cannula, renal replacement therapy, and extracorporeal membrane oxygenation support.
Conclusion: Patients with severe COVID-19 admitted to the intensive care unit exhibited a considerable morbidity and mortality, demanding substantial organ support, and prolonged intensive care unit and hospital stay.
Databáze: MEDLINE
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