Association of coronary calcification with prognosis of Covid-19 patients without known heart disease.

Autor:	Possari RY; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil., Andrade-Gomes HJ; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil.; Imagem Cardíaca, Prevent Senior, São Paulo, SP, Brasil.; Imagem Cardíaca, United Health Group, São Paulo, SP, Brasil., Mello VC; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil., Galdeano EA; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil.; Departamento de Medicina Interna, Hospital de Caridade São Vicente de Paulo, Jundiaí, SP, Brasil., Aguiar-Filho LF; Imagem Cardíaca, Prevent Senior, São Paulo, SP, Brasil.; Imagem Cardíaca, United Health Group, São Paulo, SP, Brasil.; Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brasil., Bittencourt MS; Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.; Laboratório DASA, São Paulo, SP, Brasil.; University of Pittsburgh Medical Center and University of Pittsburgh, Pittsburgh, PA, USA., Ponte EV; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil., Bertoche LR; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil., Caio LRS; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil., Rodrigues JD; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil., Alcantara FB; Departamento de Regulação da Saúde, Prefeitura de Jundiaí, Jundiaí, SP, Brasil., Freitas MAC; Departamento de Medicina Interna, Hospital de Caridade São Vicente de Paulo, Jundiaí, SP, Brasil., Sarinho JCGC; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil.; Departamento de Medicina Interna, Hospital de Caridade São Vicente de Paulo, Jundiaí, SP, Brasil., Cervigne NK; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil., Rodrigues WM; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil.; Departamento de Medicina Interna, Hospital de Caridade São Vicente de Paulo, Jundiaí, SP, Brasil., Aprahamian I; Departamento de Medicina Interna, Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brasil.; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jazyk:	angličtina
Zdroj:	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2021 Dec 03; Vol. 54 (12), pp. e11681. Date of Electronic Publication: 2021 Dec 03 (Print Publication: 2021).
DOI:	10.1590/1414-431X2021e11681
Abstrakt:	Risk factors that determine the severity of Covid-19 have not been fully elucidated. The aim of this study was to evaluate the role of coronary artery calcification (CAC) as a risk factor for death or mechanical ventilation (MV) of patients without known heart disease infected with Covid-19. We analyzed 283 consecutive in-patients with acute respiratory symptoms with chest computed tomography (chest-CT), without previous heart disease, and criteria for Covid-19 (RT-PCR positive and/or typical clinical and chest-CT findings). CAC was classified by the number of coronary segments affected as absent (0), mild (1-3), and severe calcification (more than 3). The association between CAC, CAC severity, and death or MV due to severe respiratory failure was assessed by logistic regression. The mean age was 58.7±15.7 years and 54.1% were men. Patients with CAC were older, more likely to have hypertension, and less likely to be obese. CAC was present in 75 patients (26.5%), of which 42 had a mild calcification and 33 had severe calcification, and was associated with death (OR=2.35, 95%CI: 1.01-5.48) or MV (OR=2.72, 95%CI: 1.20-6.20) adjusted for multiple confounders, with significant and increased odds ratio for the severe form of CAC (death: OR=3.70, 95%CI: 1.20-11.42; MV: OR=3.30, 95%CI: 1.09-9.95). We concluded that CAC was an independent risk factor for death or MV in Covid-19 patients without previous heart disease, particularly for those with severe calcification. CAC can be easily visualized on common chest-CT, widely used in evaluation of moderate to severe Covid-19.
Databáze:	MEDLINE
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