A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity.

Autor:	Nugent JL; Department of Surgery, University of Minnesota, MN, USA.; Preclinical Research Center, Department of Surgery, University of Minnesota, 295 Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St. Paul, MN 55108, USA., Singh A; Department of Surgery, University of Minnesota, MN, USA.; Schulze Diabetes Institute, Department of Surgery, University of Minnesota, MN, USA., Wirth KM; Department of Surgery, University of Minnesota, MN, USA., Oppler SH; Department of Surgery, University of Minnesota, MN, USA.; Preclinical Research Center, Department of Surgery, University of Minnesota, 295 Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St. Paul, MN 55108, USA., Hocum Stone L; Department of Surgery, University of Minnesota, MN, USA.; Preclinical Research Center, Department of Surgery, University of Minnesota, 295 Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St. Paul, MN 55108, USA., Janecek JL; Department of Surgery, University of Minnesota, MN, USA.; Preclinical Research Center, Department of Surgery, University of Minnesota, 295 Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St. Paul, MN 55108, USA., Sheka AC; Department of Surgery, University of Minnesota, MN, USA., Kizy S; Department of Surgery, University of Minnesota, MN, USA., Moore MEG; Department of Surgery, University of Minnesota, MN, USA.; Preclinical Research Center, Department of Surgery, University of Minnesota, 295 Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St. Paul, MN 55108, USA., Staley C; Department of Surgery, University of Minnesota, MN, USA.; BioTechnology Institute, University of Minnesota, MN, USA., Hering BJ; Department of Surgery, University of Minnesota, MN, USA.; Schulze Diabetes Institute, Department of Surgery, University of Minnesota, MN, USA., Ramachandran S; Department of Surgery, University of Minnesota, MN, USA.; Schulze Diabetes Institute, Department of Surgery, University of Minnesota, MN, USA., Ikramuddin S; Department of Surgery, University of Minnesota, MN, USA., Graham ML; Department of Surgery, University of Minnesota, MN, USA.; Preclinical Research Center, Department of Surgery, University of Minnesota, 295 Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St. Paul, MN 55108, USA.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2021 Nov 10; Vol. 24 (12), pp. 103421. Date of Electronic Publication: 2021 Nov 10 (Print Publication: 2021).
DOI:	10.1016/j.isci.2021.103421
Abstrakt:	The obesity epidemic significantly contributes to overall morbidity and mortality. Bariatric surgery is the gold standard treatment for obesity and metabolic dysfunction, yet the mechanisms by which it exerts metabolic benefit remain unclear. Here, we demonstrate a model of vertical sleeve gastrectomy (VSG) in nonhuman primates (NHP) that mimics the complexity and outcomes in humans. We also show that VSG confers weight loss and durable metabolic benefit, where equivalent caloric intake in shams resulted in significant weight gain following surgery. Furthermore, we show that VSG is associated with early, weight-independent increases in bile acids, short-chain fatty acids, and reduced visceral adipose tissue (VAT) inflammation with a polarization of VAT-resident immunocytes toward highly regulatory myeloid cells and Tregs. These data demonstrate that this strongly translational NHP model can be used to interrogate factors driving successful intervention to unravel the interplay between physiologic systems and improve therapies for obesity and metabolic syndrome. Competing Interests: The authors declare no competing interests. (© 2021 The Author(s).)
Databáze:	MEDLINE
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