Prevalence of unruptured intracranial aneurysms among first-degree relatives of Thai patients who had aneurysmal subarachnoid hemorrhage.
Autor: | Galassi W; Department of Radiology, Naresuan University, Tha Pho, Thailand., Yuyangkate W; Department of Surgery Buddhashinnaraj Hospital, Mueang, Phitsanulok, Thailand., Paholthep P; Department of Radiology, Naresuan University, Tha Pho, Thailand., Tangsriwong T; Department of Radiology, Buddhashinnaraj Hospital, Mueang, Phitsanulok, Thailand., Jaikon P; Department of Radiology, Naresuan University, Tha Pho, Thailand., Leiwan T; Department of Surgery, Naresuan University, Tha Pho, Thailand., Jiranukool J; Department of Surgery, Naresuan University, Tha Pho, Thailand., Thiarawat P; Department of Surgery, Naresuan University, Tha Pho, Thailand. |
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Jazyk: | angličtina |
Zdroj: | Surgical neurology international [Surg Neurol Int] 2021 Nov 23; Vol. 12, pp. 566. Date of Electronic Publication: 2021 Nov 23 (Print Publication: 2021). |
DOI: | 10.25259/SNI_741_2021 |
Abstrakt: | Background: The prevalence of familial unruptured intracranial aneurysm (UIA) in Thai population was unknown. Methods: Our study population comprised first-degree relatives of patients who were diagnosed with aneurysmal subarachnoid hemorrhage (aSAH) in two cerebrovascular neurosurgical centers from January 2018 to December 2018. The volunteers underwent three-dimensional time-of-flight magnetic resonance angiography for screening intracranial aneurysms (IA). Those who were reported positive or suspected of IA then underwent computed tomography angiography for confirmation. Results: We identified 12 patients who had 12 unruptured IAs (UIAs) from among 93 first-degree relatives. The prevalence of UIA among our study population was 12.9%. An estimated prevalence of UIA among Thai population was 9.05% (95% confidence interval [CI] 7.32-10.78). Of the 93 relatives, 84 had only one first-degree relative who suffered aSAH. Siblings posed a higher risk for UIA than offspring (16% vs. 9.5%), but the difference was not statistically significant (odds ratio 1.810, 95% CI 0.50-6.50, P = 0.274). The most common aneurysm location was the anterior cerebral artery territory (50%). Conclusion: The prevalence of familial UIA in a Thai population was relatively high. There was no significant between-group difference in the occurrence of UIA between the siblings and offspring of the aSAH patients. Competing Interests: There are no conflicts of interest. (Copyright: © 2021 Surgical Neurology International.) |
Databáze: | MEDLINE |
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