Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis.

Autor: Tiwari S; Department of Medicine, Bharatpur Central Hospital, Chitwan, Nepal., Kc N; Emergency Unit, Sumeru City Hospital, Kathmandu, Nepal., Thapa S; Department of Medicine, Bharatpur Central Hospital, Chitwan, Nepal., Ghimire A; Department of Medicine, Bharatpur Central Hospital, Chitwan, Nepal., Bijukchhe S; Patan Academy of Health Sciences, Lalitpur, Nepal., Sah GS; Department of Medical Oncology Unit II, B P Koirala Memorial Cancer Hospital, Chitwan, Nepal., Isnuwardana R; Department of Public Health and Community Medicine, Mulawarman University, Samarinda, Indonesia.
Jazyk: angličtina
Zdroj: Middle East Fertility Society journal [Middle East Fertil Soc J] 2021; Vol. 26 (1), pp. 44. Date of Electronic Publication: 2021 Dec 02.
DOI: 10.1186/s43043-021-00089-w
Abstrakt: Background: The novel beta-coronavirus disease (COVID-19) has infected millions of people globally with high risk among males than females. However, the effect of COVID-19 andrology is still a subject of dispute. We planned to analyze the overall consequences of COVID-19 on semen parameters and male sex hormones.
Main Text: Systematic search was performed on MEDLINE and Scopus database until 11 June 2021. We included observational studies, which reported mean ± standard deviation of the semen parameters and serum sex hormones of those reproductive-aged males recovered from COVID-19 and controls who did not suffered from COVID-19. We used Random-effect model to pool the studies, as heterogeneity was present. The Q test and I 2 evaluated heterogeneity. All articles were assessed with their quality and publication bias.We assessed 966 articles for eligibility and found seven eligible studies. These 7 studies included 934 participants with mean age 37.34 ± 10.5 years. Random-effect model meta-analysis showed that men who recovered from COVID-19 had semen parameters less than those who had not suffered from COVID-19. The overall mean difference (MD) [95% confidence interval (CI)] in semen volume, sperm concentration, sperm number, and progressive sperm motility was - 0.20 (- 0.45, 0.05) ml, - 16.59 (- 34.82, 1.65) millions/ml, - 45.44 (- 84.56, - 6.31) millions per ejaculate, - 1.73 (- 8.20, 4.75) percentage respectively. Considering sex hormones, luteinizing hormone and prolactin levels were higher among those recovered with a significant MD (95% CI) of 3.47 (1.59, 5.35)U l -1 and 3.21 (1.71, 4.72)ng ml -1 respectively.
Conclusion: We found that COVID-19 affects both semen parameters and sexual hormones. However, the mechanism for testicular involvement remains doubtful.
Trial Registration: PROSPERO CRD42021259445.
Supplementary Information: The online version contains supplementary material available at 10.1186/s43043-021-00089-w.
Competing Interests: Competing interestsAll authors declare that they have no competing interests.
(© The Author(s) 2021.)
Databáze: MEDLINE
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