Neuroglobin, clues to function and mechanism.

Autor: Exertier C; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza, Università di Roma, P.le A. Moro 5, 00185, Rome, Italy., Montemiglio LC; Institute of Molecular Biology and Pathology, National Research Council, P.le A. Moro 5, 00185, Rome, Italy., Freda I; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza, Università di Roma, P.le A. Moro 5, 00185, Rome, Italy., Gugole E; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza, Università di Roma, P.le A. Moro 5, 00185, Rome, Italy., Parisi G; Center for Life Nanoscience, Istituto Italiano di Tecnologia, 00161, Rome, Italy., Savino C; Institute of Molecular Biology and Pathology, National Research Council, P.le A. Moro 5, 00185, Rome, Italy. Electronic address: carmelinda.savino@cnr.it., Vallone B; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza, Università di Roma, P.le A. Moro 5, 00185, Rome, Italy. Electronic address: beatrice.vallone@uniroma1.it.
Jazyk: angličtina
Zdroj: Molecular aspects of medicine [Mol Aspects Med] 2022 Apr; Vol. 84, pp. 101055. Date of Electronic Publication: 2021 Dec 06.
DOI: 10.1016/j.mam.2021.101055
Abstrakt: Neuroglobin is expressed in vertebrate brain and belongs to a branch of the globin family that diverged early in evolution. Sequence conservation and presence in nervous cells of several taxa suggests a relevant role in the nervous system, with tight structural restraints. Twenty years after its discovery, a rich scientific literature provides convincing evidence of the involvement of neuroglobin in sustaining neuron viability in physiological and pathological conditions however, a full and conclusive picture of its specific function, or set of functions is still lacking. The difficulty of unambiguously assigning a precise mechanism and biochemical role to neuroglobin might arise from the participation to one or more cell mechanism that redundantly guarantee the functioning of the highly specialized and metabolically demanding central nervous system of vertebrates. Here we collect findings and hypotheses arising from recent biochemical, biophysical, structural, in cell and in vivo experimental work on neuroglobin, aiming at providing an overview of the most recent literature. Proteins are said to have jobs and hobbies, it is possible that, in the case of neuroglobin, evolution has selected for it more than one job, and support to cover for its occasional failings. Disentangling the mechanisms and roles of neuroglobin is thus a challenging task that might be achieved by considering data from different disciplines and experimental approaches.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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