Effect of catheter ablation on clinical outcomes in patients with atrial fibrillation and significant functional mitral regurgitation.
| Autor: | Wu JT; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China. wujintao666@126.com., Zhao DQ; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China., Zhang FT; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China., Liu XJ; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China., Hu J; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China., Zhang LM; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China., Fan XW; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China., Yang HT; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China., Yan LJ; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China., Liu JJ; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China., Wang SL; Department of Cardiology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China. |
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| Jazyk: | angličtina |
| Zdroj: | BMC cardiovascular disorders [BMC Cardiovasc Disord] 2021 Dec 07; Vol. 21 (1), pp. 587. Date of Electronic Publication: 2021 Dec 07. |
| DOI: | 10.1186/s12872-021-02397-5 |
| Abstrakt: | Background: In patients with atrial fibrillation (AF) and functional mitral regurgitation (MR), catheter ablation reduces the severity of MR and improves cardiac remodeling. However, its effects on prognosis are uncertain. Methods: This retrospective study included 151 consecutive patients with AF and functional MR, 82 (54.3%) of whom were treated by catheter ablation (Ablation group) and 69 (45.7%) with drug therapy without ablation (Non-ablation group). Forty-three pairs of these patients were propensity matched on the basis of age, CHA Results: Patients in the Ablation group showed a significant decrease in the severity of MR (p < 0.001), a significant decrease in the left atrial diameter (p = 0.010), and significant improvement in the left ventricular ejection fraction (p = 0.015). However, patients in the Non-ablation group showed only a significant decrease in the severity of MR (p = 0.004). The annual incidence of the studied events was 4.9% in the Ablation group and 16.7% in the Non-ablation group, the incidence being significantly lower in the ablation than Non-ablation group (p = 0.026) according to Kaplan-Meier curve analyses. According to multivariate Cox regression analysis, catheter ablation therapy (hazard ratio [HR] 0.27, 95% confidence interval [CI] 0.09-0.84; p = 0.024) and heart failure at baseline (HR 3.84, 95% CI 1.07-13.74; p = 0.038) were independent predictors of the incidence of the studied events. Conclusions: Among patients with AF and functional MR, catheter ablation was associated with a significantly lower combined risk of heart failure-related hospitalization and stroke than in a matched cohort of patients receiving drug therapy alone. (© 2021. The Author(s).) |
| Databáze: | MEDLINE |
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