The role of spray-drying atmosphere on fridericia chica (bonpl.) L.G. Lohmann standardized extract production for wound healing activity.

Autor: Sousa IMO; Postgraduate Program in Medical Sciences - Faculty of Medical Science - FCM; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA) at Campinas State University (UNICAMP), and Faculty of Pharmaceutical Science, UNICAMP, Campinas, SP, Brazil., Rivera GA; Laboratory of Foodomics, Institute of Food Science Research, CIAL, CSIC, Madrid, Spain., Pinto D; Department of Physiological Science Dental School, UNICAMP, Piracicaba-São Paulo, Brazil., Queiroz NCA; Postgraduate Program in Medical Sciences - Faculty of Medical Science - FCM; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA) at Campinas State University (UNICAMP), and Faculty of Pharmaceutical Science, UNICAMP, Campinas, SP, Brazil., Bastos VIC; Department of Physiological Science Dental School, UNICAMP, Piracicaba-São Paulo, Brazil., Braga LEO; Postgraduate Program in Medical Sciences - Faculty of Medical Science - FCM; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA) at Campinas State University (UNICAMP), and Faculty of Pharmaceutical Science, UNICAMP, Campinas, SP, Brazil., Palmeira JD; Department of Biology & CESAM, University of Aveiro, Aveiro, Portugal., Amaral H; Department of Biology & CESAM, University of Aveiro, Aveiro, Portugal., Ferreira HMN; Department of Biology & CESAM, University of Aveiro, Aveiro, Portugal., Oliveira HCC, Gonçalves FJM, Ruiz ALTG; UCIBIO/REQUIMTE, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira., Ibañez E; LAQV/REQUIMTE, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira., Oliveira BPP; Department of Physiological Science Dental School, UNICAMP, Piracicaba-São Paulo, Brazil., Foglio MA; Postgraduate Program in Medical Sciences - Faculty of Medical Science - FCM; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA) at Campinas State University (UNICAMP), and Faculty of Pharmaceutical Science, UNICAMP, Campinas, SP, Brazil.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2022 Sep; Vol. 36 (18), pp. 4799-4803. Date of Electronic Publication: 2021 Dec 08.
DOI: 10.1080/14786419.2021.2012773
Abstrakt: Fridericia chica (Bonpl.) L.G. Lohmann (synonym Arrabidaea chica Verlot) is widely used in Brazilian folk medicine. Considering overcoming pitfalls of scaling up production of plant extracts, herein the effects of N 2 atmosphere for extract spray-drying process is reported. Samples were monitored by in vitro antioxidant activity and microbiological evaluation. The drying atmosphere influenced 3-deoxyanthocyanines content when using air as atomizing gas, decreasing carajurin (37.5%) content with concomitant increase in luteolin yield (24.1%). Both drying processes preserved the pharmacological activity. In the cell migration test with HaCaT cells, the extract dried under air flow (5 μg/mL) promoted wound closure by 78% (12 hours) whereas the extract dried using N 2 flow promoted 49% (12 hours), with 98% closure (12 hours) for the positive control. The antimicrobial evaluation for Staphylococcus aureus did not differ within drying atmospheres, with MIC (minimum inhibitory concentration) at 0.39 mg/mL. Therefore, the drying process reported herein did not interfere with the biological activity's outcome.
Databáze: MEDLINE
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