Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project.

Autor:	Estévez-López F; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., Guerrero-González JM; GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain., Salazar-Tortosa D; Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA., Camiletti-Moirón D; Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz., Gavilán-Carrera B; Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz., Aparicio VA; Department of Physiology, Faculty of Pharmacy., Acosta-Manzano P; Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada., Álvarez-Gallardo IC; Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz., Segura-Jiménez V; Instituto de Investigación Biosanitaria ibs.GRANADA.; Hospital Universitario Virgen de las Nieves of Granada.; GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz., Soriano-Maldonado A; Department of Education, Faculty of Education Sciences, and SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain., Geenen R; Department of Psychology, Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands., Delgado-Fernández M; Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada., Martínez-González LJ; GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain., Ruiz JR; PROFITH - 'PROmoting FITness and Health Through Physical Activity' - Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences., Álvarez-Cubero MJ; GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain.; Department of Biochemistry and Molecular Biology III, Faculty of Medicine, PTS, University of Granada, Granada, Spain.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 Aug 03; Vol. 61 (8), pp. 3180-3191.
DOI:	10.1093/rheumatology/keab911
Abstrakt:	Objectives: It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also important. Thus, the purpose of the present study was to test the association of 64 polymorphisms (34 candidate genes) and the gene-gene, gene-PA and gene-sedentary behaviour interactions with pain and pain-related cognitions in women with FM. Methods: Saliva samples from 274 women with FM [mean (s.d.) age 51.7 (7.7) years] were collected for extracting DNA. We measured PA and sedentary behaviour by accelerometers for a week, pain with algometry and questionnaires, and pain-related cognitions with questionnaires. To assess the robustness of the results, a meta-analysis was also performed. Results: The rs6311 and rs6313 polymorphisms (5-hydroxytryptamine receptor 2A, HTR2A) were individually related to algometer scores. The interaction of rs4818 (catechol-O-methyltransferase, COMT) and rs1799971 (opioid receptor μ gene, OPRM1) was related to pain catastrophizing. Five gene-behaviour interactions were significant: the interactions of sedentary behaviour with rs1383914 (adrenoceptor alpha 1A, ADRA1A), rs6860 (charged multivesicular body protein 1A, CHMP1A), rs4680 (COMT), rs165599 (COMT) and rs12994338 (SCN9A) on bodily pain subscale of the Short Form 36. Furthermore, the meta-analysis showed an association between rs4680 (COMT) and severity of FM symptoms (codominant model, P-value 0.032). Conclusion: The HTR2A gene (individually), COMT and OPRM1 gene-gene interaction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A, COMT and SCN9A genes were associated with pain-related outcomes. Collectively, findings from the present study indicate a modest contribution of genetics and gene-sedentary behaviour interaction to pain and pain catastrophizing in women with FM. Future research should examine whether reducing sedentary behaviour is particularly beneficial for reducing pain in women with genetic susceptibility to pain. (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology.)
Databáze:	MEDLINE
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