Association between serum inflammatory parameters and the disease severity in COVID-19 patients.

Autor: Mardani R; Department of Clinical Biochemistry, Hamadan University of Medical Science, Hamadan, Iran., Namavar M; Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran., Ghorbi E; Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran., Shoja Z; Virology Department, Pasteur Institute of Iran, Tehran, Iran., Zali F; Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran., Kaghazian H; Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran.; Department of Research and Development, Production and Research Complex, Pasteur Institut of Iran, Tehran, Iran., Aghasadeghi MR; Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran.; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran., Sadeghi SA; Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran.; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran., Sabeti S; Pathology Ward, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Darazam IA; Infectious Diseases, and Tropical Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ahmadi N; Department of Medical Lab Technology, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mousavi-Nasab SD; Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran.; Department of Research and Development, Production and Research Complex, Pasteur Institut of Iran, Tehran, Iran.
Jazyk: angličtina
Zdroj: Journal of clinical laboratory analysis [J Clin Lab Anal] 2022 Jan; Vol. 36 (1), pp. e24162. Date of Electronic Publication: 2021 Dec 07.
DOI: 10.1002/jcla.24162
Abstrakt: Objective: Most patients infected with the novel coronavirus (SARS-CoV-2), as the causative agent of COVID-19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID-19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity.
Methods: In this prospective cross-sectional study, 50 patients with COVID-19 and 20 patients without COVID-19 were enrolled. According to ICU admission criteria, patients were divided into two groups of non-severe and severe. Differences in the serum levels of C-reactive protein (CRP), IL-6, and TNF-α, as well as erythrocyte sedimentation rate (ESR), lymphocytes (LYM) count, and neutrophils (NEU) count between the two groups were determined and analyzed.
Results: Out of the 50 patients with COVID-19, 14 were diagnosed as severe cases. There was no significant difference between the two groups of COVID-19 patients in terms of gender and age. Blood tests of COVID-19 patients showed a significant decrease and increase in NEU and LYM counts, respectively. There were significant differences in the serum levels of IL-6, TNF-α, and CRP between the severe and non-severe groups, which were higher in the severe group. Also, there was a significant correlation between the disease severity and CRP with ESR (r = 0.79), CRP with IL-6 (r = 0.74), LYM with NEU (r = -0.97), and ESR with TNF-α (r = 0.7).
Conclusion: The findings of this study, as the first study in Iran, suggest that the levels of IL-6, TNF-α, ESR, and CRP could be used to predict the severity of COVID-19 disease.
(© 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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