High-fat diets on the enteric nervous system: Possible interactions and mechanisms underlying dysmotility.

Autor: Almeida PP; Postgraduate Program in Cardiovascular Sciences, Fluminense Federal University, Niterói, Brazil., Valdetaro L; Postgraduate Program in Neurosciences, Fluminense Federal University, Niterói, Brazil., Thomasi BBM; Postgraduate Program in Neurosciences, Fluminense Federal University, Niterói, Brazil., Stockler-Pinto MB; Postgraduate Program in Cardiovascular Sciences, Fluminense Federal University, Niterói, Brazil.; Postgraduate Program in Nutrition Sciences, Fluminense Federal University, Niterói, Brazil., Tavares-Gomes AL; Postgraduate Program in Neurosciences, Fluminense Federal University, Niterói, Brazil.
Jazyk: angličtina
Zdroj: Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2022 Apr; Vol. 23 (4), pp. e13404. Date of Electronic Publication: 2021 Dec 06.
DOI: 10.1111/obr.13404
Abstrakt: Obesity is a chronic disease that affects various physiological systems. Among them, the gastrointestinal tract appears to be a main target of this disease. High-fat diet (HFD) animal models can help recapitulate the classic signs of obesity and present a series of gastrointestinal alterations, mainly dysmotility. Because intestinal motility is governed by the enteric nervous system (ENS), enteric neurons, and glial cells have been studied in HFD models. Given the importance of the ENS in general gut physiology, this review aims to discuss the relationship between HFD-induced neuroplasticity and gut dysmotility observed in experimental models. Furthermore, we highlight components of the gut environment that might influence enteric neuroplasticity, including gut microbiota, enteric glio-epithelial unit, serotonin release, immune cells, and disturbances such as inflammation and oxidative stress.
(© 2021 World Obesity Federation.)
Databáze: MEDLINE
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