Influence of nocturnal hypoxemia on follow-up course after type B acute aortic syndrome.

Autor: Delsart P; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France. delsartpascal@yahoo.fr.; Vascular Medicine and Hypertension Department, Institut-Coeur-Poumon, Boulevard Pr Leclercq, 59037, Lille Cedex, France. delsartpascal@yahoo.fr., Soquet J; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France.; University of Lille, CHU Lille, 59000, Lille, France., Pierache A; Service d'épidémiologie et de santé publique, University of Lille, CHU Lille, 59000, Lille, France., Dedeken M; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France., Fry S; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France., Mallart A; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France., Pontana F; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France.; University of Lille, CHU Lille, 59000, Lille, France., Azzaoui R; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France., Juthier F; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France.; University of Lille, CHU Lille, 59000, Lille, France., Sobocinski J; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France.; University of Lille, CHU Lille, 59000, Lille, France., Mounier-Vehier C; Lille, Institut Cœur Poumon, Bd Pr Leclercq, 59000, Lille, France.; University of Lille, CHU Lille, 59000, Lille, France.; Vascular Medicine and Hypertension Department, Institut-Coeur-Poumon, Boulevard Pr Leclercq, 59037, Lille Cedex, France.
Jazyk: angličtina
Zdroj: BMC pulmonary medicine [BMC Pulm Med] 2021 Dec 06; Vol. 21 (1), pp. 401. Date of Electronic Publication: 2021 Dec 06.
DOI: 10.1186/s12890-021-01778-y
Abstrakt: Introduction: Association between sleep nocturnal breathing disorders and acute aortic syndrome (AAS) has been described but mid-term data are scarce.
Objectives: We assessed the prognostic value of sleep apnea parameters and their relationship with aortic morphology after the onset of a type B AAS.
Methods: Between January 2010 and January 2018, sleep apnea screening in post type B AAS was prospectively performed. The association of sleep apnea parameters with aortic morphology and aortic expansion during follow-up was studied.
Results: Over the 8-year-study period, 103 patients were included, with a mean age of 57.8 ± 12.1 years old. Median follow-up was 25.0 months (11.0-51.0). Thirty-two patients (31%) required aortic stenting during the acute phase. In patients treated by aortic stenting, the descending thoracic aortic diameter was positively associated with a higher percentage of nocturnal time of saturation ≤ 90% after adjustment (p = 0.016). During follow-up, the nocturnal time of saturation ≤ 90% in patients treated by medical therapy was the only parameter associated with significant aortic expansion rate (r = 0.26, p = 0.04). Thirty-eight patients started and sustained nocturnal ventilation during follow-up. The association between aortic expansion rate and nocturnal time of saturation ≤ 90% did not persist during follow-up after adjustment on nocturnal ventilation initiation (r = 0.25, p = 0.056).
Conclusions: Nocturnal hypoxemia parameters are positively associated with the max onset aortic diameter and significant aortic growth after type B AAS. Nocturnal ventilation seems to mitigate aortic expansion during follow-up.
(© 2021. The Author(s).)
Databáze: MEDLINE
Externí odkaz: