Solitary manifestations of primary B-lymphoblastic lymphoma of the spine: Systematic literature review with case illustration.

Autor: Croci DM; Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175N Medical Drive East, Salt Lake City, UT 84132, USA. Electronic address: neuropub@hsc.utah.edu., Gamboa NT; Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175N Medical Drive East, Salt Lake City, UT 84132, USA., Osman AEG; Department of Internal Medicine, Division of Hematology & Hematologic Malignancies, 2000 Circle of Hope, Salt Lake City, UT 84112, USA., Maese L; Department of Pediatric Hematology and Oncology, University of Utah & Huntsman Cancer Institute, Salt Lake City, UT, USA., Mazur M; Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175N Medical Drive East, Salt Lake City, UT 84132, USA., Bisson EF; Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175N Medical Drive East, Salt Lake City, UT 84132, USA., Dailey AT; Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175N Medical Drive East, Salt Lake City, UT 84132, USA.
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2022 Jan; Vol. 212, pp. 107064. Date of Electronic Publication: 2021 Nov 24.
DOI: 10.1016/j.clineuro.2021.107064
Abstrakt: Background: Given the locally destructive osteolytic nature of primary B-cell lymphoblastic lymphoma (B-LBL) of the spine, careful attention is needed to identify clinical signs and symptoms as well as radiological findings of spinal instability because these lesions may warrant resection, decompression, and instrumentation with posterolateral fusion. Our objective was to summarize the presenting symptoms, clinical features, potential treatment modalities, and clinical outcome of cases described in the literature.
Methods: We undertook a systematic literature review to identify all relevant cases and case series describing primary manifestations B-LBL of the spine using Pubmed/Medline. We summarized the findings in accordance with the PRISMA guidelines. We also present a case illustration.
Results: Together with our case, 9 cases of primary B-LBL of the spine were identified in 6 male and 3 female patients (age 8-58 years, median 31 years). Back pain was the most common symptom, and five patients also had neurological signs of spinal cord compression. T1-weighted MRI contrast enhancement was seen in 5 cases. Surgery was performed in 5 patients with progression of neurological deficits. Steroid treatment was also given in 3 patients preoperatively. Seven patients had chemotherapy after diagnosis. During follow-up of 1 month to 1 year, 2 cases of recurrence and 4 cases of complete remission were noted; however, with the short follow-up time, patient prognosis overall remains unclear.
Conclusions: Primary B-LBL of the spine represents a rare clinical entity whose management mandates a multidisciplinary approach. Careful attention must be paid to the neurological status of the patient, as well as to imaging that may highlight potential local instability of the spine.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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