Callous-Unemotional Traits Moderate the Relationship Between Irritability and Threatening Responding.

Autor:	Zhang R; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States., Bashford-Largo J; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States., Lukoff J; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States., Elowsky J; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States., Carollo E; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States., Schwartz A; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States., Dobbertin M; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States., Bajaj S; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States., Blair KS; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States., Leibenluft E; Section on Mood Dysregulation and Neuroscience, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States., Blair RJR; Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2021 Nov 16; Vol. 12, pp. 617052. Date of Electronic Publication: 2021 Nov 16 (Print Publication: 2021).
DOI:	10.3389/fpsyt.2021.617052
Abstrakt:	Background: Irritability and callous-unemotional (CU; reduced guilt/empathy) traits vary dimensionally in the typically developing population but may be particularly marked in youth with conduct disorder (CD). While these dimensional traits are positively correlated, they have been associated with divergent forms of dysfunction, particularly with respect to threat processing (i.e., irritability with increased, and CU traits with decreased, threat responsiveness). This suggests that interactions between these two dimensions may be complex at the neurobiological level. However, this issue has received minimal empirical attention. Methods: The study included 105 adolescents (typically developing and cases with CD; N = 59). They were scanned with fMRI during a looming threat task that involved images of threatening and neutral human faces or animals that appeared to be either looming or receding. Results: Significant irritability-by-CU traits-by-Direction-by-Emotion interactions were seen within right thalamus/PAG, left lingual gyrus and right fusiform gyrus; irritability was positively associated with the BOLD response for Looming Threatening vs. Receding Threatening trials, particularly for youth with low CU traits. In contrast, CU traits were negatively associated with the same differential BOLD response but particularly for youth showing higher levels of irritability. Similar findings were seen within left ventral anterior and posterior cingulate cortices, though the addition of the interaction with CU traits was only seen at slightly more lenient thresholds. Conclusions: The results support previous work linking irritability to increased, and CU traits to reduced, threat responsiveness. However, for adolescents with high irritability, if CU traits are also high, the underlying neuropathology appears to relate to reduced, rather than increased, threat responsiveness. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Zhang, Bashford-Largo, Lukoff, Elowsky, Carollo, Schwartz, Dobbertin, Bajaj, Blair, Leibenluft and Blair.)
Databáze:	MEDLINE
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