Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice.

Autor:	Climer LK; Department of Biology, Baylor University, Waco, TX, United States., Hornak AJ; Department of Biology, Baylor University, Waco, TX, United States., Murtha K; Department of Biology, Baylor University, Waco, TX, United States., Yang Y; Department of Biology, Baylor University, Waco, TX, United States., Cox AM; Department of Biology, Baylor University, Waco, TX, United States., Simpson PL; Department of Biology, Baylor University, Waco, TX, United States., Le A; Department of Biology, Baylor University, Waco, TX, United States., Simmons DD; Department of Biology, Baylor University, Waco, TX, United States.; Department of Psychology and Neuroscience, Baylor University, Waco, TX, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2021 Nov 15; Vol. 13, pp. 749729. Date of Electronic Publication: 2021 Nov 15 (Print Publication: 2021).
DOI:	10.3389/fnagi.2021.749729
Abstrakt:	Ca 2+ signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) is a Ca 2+ binding protein (CaBP) preferentially expressed in outer hair cells (OHCs) of the cochlea and few other specialized cell types. Here, we expand on our previous reports and show that OCM delays hearing loss in mice of two different genetic backgrounds: CBA/CaJ and C57Bl/6J. In both backgrounds, genetic disruption of Ocm leads to early progressive hearing loss as measured by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). In both strains, loss of Ocm reduced hearing across lifetime (hearing span) by more than 50% relative to wild type (WT). Even though the two WT strains have very different hearing spans, OCM plays a considerable and similar role within their genetic environment to regulate hearing function. The accelerated age-related hearing loss (ARHL) of the Ocm KO illustrates the importance of Ca 2+ signaling in maintaining hearing health. Manipulation of OCM and Ca 2+ signaling may reveal important clues to the systems of function/dysfunction that lead to ARHL. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Climer, Hornak, Murtha, Yang, Cox, Simpson, Le and Simmons.)
Databáze:	MEDLINE
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