Unexpected arterial thrombosis and acute limb ischemia in COVID-19 patients. Results from the Ibero-Latin American acute arterial thrombosis registry in COVID-19: (ARTICO-19).

Autor:	Gonzalez-Urquijo M; Tecnologico de Monterrey, 27746School of Medicine and Health Sciences, Monterrey, México.; Instituto de Cardiología y Medicina Vascular, TecSalud, San Pedro Garza García, México., Gonzalez-Rayas JM; Tecnologico de Monterrey, 27746School of Medicine and Health Sciences, Monterrey, México., Castro-Varela A; Tecnologico de Monterrey, 27746School of Medicine and Health Sciences, Monterrey, México., Hinojosa-Gonzalez DE; Tecnologico de Monterrey, 27746School of Medicine and Health Sciences, Monterrey, México., Ramos-Cazares RE; Tecnologico de Monterrey, 27746School of Medicine and Health Sciences, Monterrey, México., Vazquez-Garza E; Instituto de Cardiología y Medicina Vascular, TecSalud, San Pedro Garza García, México., Paredes-Vazquez JG; Tecnologico de Monterrey, 27746School of Medicine and Health Sciences, Monterrey, México.; Instituto de Cardiología y Medicina Vascular, TecSalud, San Pedro Garza García, México., Castillo-Perez M; Tecnologico de Monterrey, 27746School of Medicine and Health Sciences, Monterrey, México., Jerjes-Sanchez C; Tecnologico de Monterrey, 27746School of Medicine and Health Sciences, Monterrey, México.; Instituto de Cardiología y Medicina Vascular, TecSalud, San Pedro Garza García, México., Fabiani MA; Tecnologico de Monterrey, 27746School of Medicine and Health Sciences, Monterrey, México.; Instituto de Cardiología y Medicina Vascular, TecSalud, San Pedro Garza García, México.
Jazyk:	angličtina
Zdroj:	Vascular [Vascular] 2022 Dec; Vol. 30 (6), pp. 1107-1114. Date of Electronic Publication: 2021 Dec 04.
DOI:	10.1177/17085381211052033
Abstrakt:	Objective: Few studies have focused on arterial thrombosis and acute limb ischemia in COVID-19. This international registry intended to study the spectrum of clinical characteristics, therapeutic trends, and outcomes in a cohort of Ibero-Latin American patients with arterial thrombosis or acute limb ischemia and COVID-19. Methods: Data were retrospectively obtained from 21 centers in 9 countries. Patients with proven COVID-19 and asymptomatic or symptomatic arterial thrombosis were included. COVID-19 diagnosis was established by RT-PCR assay or IgM serology plus suggestive clinical/radiographical findings. We recorded and analyzed variables related to demography, clinical presentation, therapeutic trends, and outcomes. Results: Eighty one patients were included in the registry. In 38.3%, acute limb ischemia symptoms were the first manifestation of COVID-19. Non-surgical management was more frequent in severe cases than surgical interventions, 11.1% vs. 88.9%, respectively ( p = 0.004). Amputation rates were similar between all COVID severity groups ( p = 0.807). Treatment was classified as non-surgical, open surgical, and endovascular treatment. Further analysis revealed an equal frequency of major leg amputation between treatment groups and increased mortality in patients with non-surgical management. However, multivariate regression analysis showed that treatment choices are associated with disease severity, with significant non-surgical treatment in critical patients; thus, mortality is related to the severity and confounds treatment analysis. Conclusion: Arterial thrombosis can be the initial symptom of a patient presenting with COVID-19. Physicians and health workers should potentially suspect COVID-19 in acute ischemia cases without a known risk factor or embolic cause. More experimental and clinical research is required to understand the complex phenomenon of arterial COVID-19 induced coagulopathy fully.
Databáze:	MEDLINE
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