Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex.

Autor:	Iturriaga R; Laboratorio de Neurobiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.; Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Chile., Del Rio R; Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Chile.; Laboratory of Cardiorespiratory Control, Department of Physiology, Pontificia Universidad Católica de Chile, Santiago, Chile.; Centro de Envejecimiento y Regeneración (CARE), Pontificia Universidad Católica de Chile, Santiago, Chile., Alcayaga J; Laboratorio de Fisiología Celular, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
Jazyk:	angličtina
Zdroj:	Physiology (Bethesda, Md.) [Physiology (Bethesda)] 2022 May 01; Vol. 37 (3), pp. 128-140. Date of Electronic Publication: 2021 Dec 06.
DOI:	10.1152/physiol.00031.2021
Abstrakt:	Emergent evidence indicates that the carotid body (CB) chemoreceptor may sense systemic inflammatory molecules and is an afferent arm of the anti-inflammatory reflex. Moreover, a proinflammatory milieu within the CB is involved in the enhanced CB chemosensory responsiveness to oxygen following sustained and intermittent hypoxia. In this review, we focus on the physiopathological participation of CBs in inflammatory diseases, such as sepsis and intermittent hypoxia.
Databáze:	MEDLINE
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