Comparative study of hydrophobically modified gelatin-based sealant with commercially available sealants.

Autor: Mizuno Y; Graduate School of Science and Technology, University of Tsukuba, Ibaraki, Japan.; Polymers and Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, Ibaraki, Japan., Watanabe S; Polymers and Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, Ibaraki, Japan., Katano M; Polymers and Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, Ibaraki, Japan., Yanagihara T; Department of Thoracic Surgery, University of Tsukuba, Ibaraki, Japan., Maki N; Department of Thoracic Surgery, University of Tsukuba, Ibaraki, Japan., Sato Y; Department of Thoracic Surgery, University of Tsukuba, Ibaraki, Japan., Taguchi T; Graduate School of Science and Technology, University of Tsukuba, Ibaraki, Japan.; Polymers and Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, Ibaraki, Japan.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2022 Apr; Vol. 110 (4), pp. 909-915. Date of Electronic Publication: 2021 Dec 05.
DOI: 10.1002/jbm.a.37339
Abstrakt: Air leakage is one of the major complications related to pulmonary surgeries. To reduce this complication, we developed a decyl group (C10)-modified Alaska pollock gelatin (ApGltn) (C10-ApGltn) sealant and evaluated its practical performance against commercially available sealants, Beriplast® and DuraSeal®. C10-ApGltn was synthesized by reductive amination of the amino groups in ApGltn with decanal. C10-ApGltn was crosslinked with a poly(ethylene glycol)-based crosslinker to form a tissue sealant. The crosslinking time of the C10-ApGltn sealant was fast enough for curing on tissue and application as a spray system. Although the percent swelling of C10-ApGltn and DuraSeal was significantly greater than Beriplast, C10-ApGltn and DuraSeal exhibited excellent tissue sealing properties on pleura tissue under a long-term moist condition. Additionally, C10-ApGltn and DuraSeal did not cause severe inflammatory responses in a rat subcutaneous example. Therefore, C10-ApGltn sealant had comparable tissue sealing properties to DuraSeal under a moist condition, indicating the potential of C10-ApGltn sealant for pulmonary surgeries.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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