Frontal neural metabolite changes in schizophrenia and their association with cognitive control: A systematic review.

Autor: Dixon BJ; University of Nottingham, School of Psychology, United Kingdom. Electronic address: lpxbd1@exmail.nottingham.ac.uk., Kumar J; Cambridgeshire Community Services NHS Trust, United Kingdom., Danielmeier C; University of Nottingham, School of Psychology, United Kingdom. Electronic address: claudia.danielmeier@nottingham.ac.uk.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2022 Jan; Vol. 132, pp. 224-247. Date of Electronic Publication: 2021 Dec 02.
DOI: 10.1016/j.neubiorev.2021.11.010
Abstrakt: A large proportion of patients with schizophrenia exhibit deficits in cognitive control functions including working memory, processing speed and inhibitory control, which have been associated with frontal brain areas. In this systematic review, we investigated differences between chronic schizophrenia patients, first-episode (FEP) patients and healthy control groups in the neurometabolite levels of GABA, glutamate, glutamine and Glx in frontal brain areas. Additionally, we reviewed correlations between cognitive control functions or negative symptoms and these neurometabolite levels. Several studies reported decreased GABA or glutamate concentrations in frontal lobe areas, particularly in chronic schizophrenia patients, while the results were mixed for FEP patients. Working memory performance and prediction errors have been associated with frontal GABA and glutamate levels, and processing speed with frontomedial GABA levels in chronic patients. The relationship between metabolites and negative symptom severity was somewhat inconsistent. Future studies should take the participants' age, medication status or responsivity, disease stage and precise anatomical location of the voxel into account when comparing neurometabolite levels between schizophrenia patients and healthy controls.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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