Understanding the genetics of intracranial aneurysms: A primer.

Autor: Laurent D; Department of Neurosurgery, University of Florida, Gainesville, United States. Electronic address: Dimitri.Laurent@neurosurgery.ufl.edu., Small C; Department of Neurosurgery, University of Florida, Gainesville, United States., Lucke-Wold B; Department of Neurosurgery, University of Florida, Gainesville, United States., Dodd WS; Department of Neurosurgery, University of Florida, Gainesville, United States., Chalouhi N; Department of Neurosurgery, University of Florida, Gainesville, United States., Hu YC; Department of Neurosurgery, University of Florida, Gainesville, United States., Hosaka K; Department of Neurosurgery, University of Florida, Gainesville, United States., Motwani K; Department of Neurosurgery, University of Florida, Gainesville, United States., Martinez M; Department of Neurosurgery, University of Florida, Gainesville, United States., Polifka A; Department of Neurosurgery, University of Florida, Gainesville, United States., Koch M; Department of Neurosurgery, University of Florida, Gainesville, United States., Busl KM; Department of Neurosurgery, University of Florida, Gainesville, United States., Maciel CB; Department of Neurosurgery, University of Florida, Gainesville, United States., Hoh B; Department of Neurosurgery, University of Florida, Gainesville, United States. Electronic address: Brian.Hoh@neurosurgery.ufl.edu.
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2022 Jan; Vol. 212, pp. 107060. Date of Electronic Publication: 2021 Nov 25.
DOI: 10.1016/j.clineuro.2021.107060
Abstrakt: The genetics of intracranial aneurysms is complex. Much work has been done looking at the extracellular matrix surrounding cerebral vasculature as well as the role of matrix metalloproteinases. This comprehensive review summarizes what is known to date about the important genetic components that predispose to aneurysm formation and critically discusses the published findings. We discuss promising pre-clinical models of aneurysm formation and subarachnoid hemorrhage, and highlight avenues for future discovery, while considering limitations in the research to date. This review will further serve as a comprehensive reference guide to understand the genetic underpinnings for aneurysm pathophysiology and act as a primer for further investigation.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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