Mass spectrometry-based lipid analysis and imaging.

Autor:	Pathmasiri KC; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, United States., Nguyen TTA; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, United States., Khamidova N; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, United States., Cologna SM; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, United States; Laboratory of Integrated Neuroscience, University of Illinois at Chicago, Chicago, IL, United States. Electronic address: cologna@uic.edu.
Jazyk:	angličtina
Zdroj:	Current topics in membranes [Curr Top Membr] 2021; Vol. 88, pp. 315-357. Date of Electronic Publication: 2021 Nov 09.
DOI:	10.1016/bs.ctm.2021.10.005
Abstrakt:	Mass spectrometry imaging (MSI) is a powerful tool for in situ mapping of analytes across a sample. With growing interest in lipid biochemistry, the ability to perform such mapping without antibodies has opened many opportunities for MSI and lipid analysis. Herein, we discuss the basics of MSI with particular emphasis on MALDI mass spectrometry and lipid analysis. A discussion of critical advancements as well as protocol details are provided to the reader. In addition, strategies for improving the detection of lipids, as well as applications in biomedical research, are presented. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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