Paroxysmal sympathetic hyperactivity during traumatic brain injury.

Autor: Jafari AA; Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran., Shah M; Deccan College of Medical Sciences, Hyderabad, Telangana State, India., Mirmoeeni S; Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran., Hassani MS; Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran., Nazari S; Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran., Fielder T; University of Texas Health Science Center at San Antonio School of Medicine, San Antonio, TX, USA., Godoy DA; Neurointensive Care Unit, Sanatorio Pasteur; Hospital Carlos Malbran, Catamarca, Argentina., Seifi A; Department of Neurosurgery, Division of Neuro Critical Care, University of Texas Health Science Center at San Antonio School of Medicine, San Antonio, TX, USA. Electronic address: seifi@uthscsa.edu.
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2022 Jan; Vol. 212, pp. 107081. Date of Electronic Publication: 2021 Nov 27.
DOI: 10.1016/j.clineuro.2021.107081
Abstrakt: Traumatic brain injury (TBI) is one of the leading causes of disability, morbidity, and mortality worldwide. Some of the more common etiologies of TBI include closed head injury, penetrating head injury, or an explosive blast head injury. Neuronal damage in TBI is related to both primary injury (caused by mechanical forces), and secondary injury (caused by the subsequent tissue and cellular damages). Recently, it has been well established that Paroxysmal Sympathetic Hyperactivity (PSH), also known as "Sympathetic Storm", is one of the main causes of secondary neuronal injury in TBI patients. The clinical manifestations of PSH include recurrent episodes of sympathetic hyperactivity characterized by tachycardia, systolic hypertension, hyperthermia, tachypnea with hyperpnea, and frank diaphoresis. Given the diverse manifestations of PSH and its notable impact on the outcome of TBI patients, we have comprehensively reviewed the current evidence and discussed the pathophysiology, clinical manifestations, time of onset and duration of PSH during TBI. This article reviews the different types of head injuries that most commonly lead to PSH, possible approaches to manage and minimize PSH complications in TBI and the current prognosis and outcomes of PSH in TBI patients.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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