| Autor: |
Margetaki K; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Alexaki M; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Vittorakis E; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Roumeliotaki T; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Leventakou V; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.; Department of Health Research Governance, Ministry of Public Health, AL Rumaila, Doha, Qatar., Bempi V; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Chalkiadaki G; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Kyrtopoulos SA; Institute of Biology, Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece., Rantakokko P; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland., Kiviranta H; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland., Stephanou EG; Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, Heraklion, Greece., Kogevinas M; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública, Barcelona, Spain., Chatzi L; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Vafeiadi M; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. |
| Abstrakt: |
Accumulating evidence suggests that in utero exposures can influence the development of the immune system. Few studies have investigated whether prenatal exposure to persistent organic pollutants (POPs) is associated with allergy-related phenotypes in childhood, nor explored sex differences. We examined the association between prenatal exposure to POPs and offspring allergic outcomes in early and mid-childhood. We included 682 mother-child pairs from the prospective birth cohort Rhea. We measured dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB) and 6 polychlorinated biphenyl (PCB) congeners in maternal first trimester serum. Parents completed the questionnaires adapted from the International Study on Asthma and Allergy in Childhood (ISAAC) for allergy-related phenotypes when their children were 4 and 6 years old. We used Poisson regression models to estimate Risk Ratios. Prenatal HCB was associated with increased risk for rhinoconjunctivitis at 6 years (RR (95% CI): 2.5; (1.3, 4.8) for a doubling in the exposure). Among girls, prenatal DDE was associated with increased risk for current wheeze, current asthma and current rhinoconjunctivitis at 4 years (RR (95%CI): 1.4 (0.8, 2.6), 1.6 (1.1, 2.4) and 1.8 (1.0, 3.3) and p-interaction = 0.035, 0.027 and 0.059, respectively), with increased risk for current rhinoconjunctivitis at 6 years (RR (95%CI): 1.7 (0.7, 3.8) and p-interaction = 0.028) and total PCBs were associated with increased risk for current eczema at 4 years (RR (95%CI): 2.1 (1.1, 4.2) and p-interaction = 0.028). In boys, prenatal DDE was associated with decreased risk for current wheeze and current asthma at 4 years. Our findings suggest that even low levels of exposure to POPs prenatally may affect the development of childhood allergy-related outcomes in a sex and age-specific manner. |
