Polarization-sensitive optical coherence tomography in end-stage lung diseases: an ex vivo pilot study.

Autor:	Willemse J; LaserLaB, Department of Physics and Astronomy, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; These authors contributed equally., Wener RR; Department of Pulmonology, Antwerp University Hospital, Edegem, Belgium.; Department of Thoracic Oncology, Antwerp University Hospital, Edegem, Belgium.; Department of Pulmonary Diseases, Utrecht University Medical Center, Utrecht, The Netherlands.; These authors contributed equally., Feroldi F; LaserLaB, Department of Physics and Astronomy, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Currently with the School of Optometry, University of California, Berkeley, California 94720, USA., Vaselli M; LaserLaB, Department of Physics and Astronomy, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Kwakkel-van Erp JM; Department of Pulmonology, Antwerp University Hospital, Edegem, Belgium.; Department of Pulmonary Diseases, Utrecht University Medical Center, Utrecht, The Netherlands., van de Graaf EA; Department of Pulmonary Diseases, Utrecht University Medical Center, Utrecht, The Netherlands., Thunnissen E; Department of Pathology, Amsterdam University Medical Center, Location VUmc, Amsterdam, The Netherlands., de Boer JF; LaserLaB, Department of Physics and Astronomy, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2021 Oct 07; Vol. 12 (11), pp. 6796-6813. Date of Electronic Publication: 2021 Oct 07 (Print Publication: 2021).
DOI:	10.1364/BOE.435870
Abstrakt:	A non-invasive diagnostic tool to assess remodeling of the lung airways caused by disease is currently missing in the clinic. Measuring key features such as airway smooth muscle (ASM) thickness would increase the ability to improve diagnosis and enable treatment evaluation. In this research, polarization-sensitive optical coherence tomography (PS-OCT) has been used to image a total of 24 airways from two healthy lungs and four end-stage diseased lungs ex vivo , including fibrotic sarcoidosis, chronic obstructive pulmonary disease (COPD), fibrotic hypersensitivity pneumonitis, and cystic fibrosis. In the diseased lungs, except COPD, the amount of measured airway smooth muscle was increased. In COPD, airway smooth muscle could not be distinguished from surrounding collagen. COPD lungs showed increased alveolar size. 3D pullbacks in the same lumen provided reproducible assessment of airway smooth muscle (ASM). Image features such as thickened ASM and size/presence of alveoli were recognized in histology. The results of this study are preliminary and must be confirmed with further ex vivo and in vivo studies. PS-OCT is applicable for in vivo assessment of peribronchial and peribronchiolar lung structures and may become a valuable tool for diagnosis in pulmonology. Competing Interests: JFdB: Terumo, inc., Heidelberg Engineering, Spectrawave. (P, R), (© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.)
Databáze:	MEDLINE
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