Can the long term using of pregabalin in fibromyalgia affect the choroid and retinal nerve fiber layer?

Autor: Biçer GY; Niğde Ömer Halisdemir University School of Medicine Department of Ophthalmology, Niğde, MD, Turkey. gmz_y_06@hotmail.com., Zor KR; Niğde Ömer Halisdemir University School of Medicine Department of Ophthalmology, Niğde, MD, Turkey., Biçer KE; Niğde Ömer Halisdemir Education and Research Hospital Department of Orthopedics and Traumatology, Niğde, MD, Turkey., Küçük E; Niğde Ömer Halisdemir University School of Medicine Department of Ophthalmology, Niğde, MD, Turkey., Küçük EB; Niğde Bor Physical Medicine and Rehabilitation Hospital Department of Physical Medicine and Rehabilitation, Niğde, MD, Turkey.
Jazyk: angličtina
Zdroj: Eye (London, England) [Eye (Lond)] 2022 Dec; Vol. 36 (12), pp. 2318-2322. Date of Electronic Publication: 2021 Dec 02.
DOI: 10.1038/s41433-021-01864-9
Abstrakt: Background: In this study, the effects of long-term pregabalin use on the choroid and retinal nerve fiber layer were investigated in the fibromyalgia disease.
Methods: The patient group consisted of 41 fibromyalgia patients using pregabalin. The control group consisted of 41 newly diagnosed fibromyalgia patients who had not received any treatment yet. Choroidal and retinal nerve fiber layer thickness measurements were performed with Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA, USA) 30 minutes after pupil dilation with 1% tropicamide.
Results: There was no difference in subfoveal choroidal thickness, nasal choroidal thickness and temporal choroidal thickness between the patient and control groups (p > 0.05). Increasing the duration of drug use within the patient group was found to thin the retinal nerve fiber layer (p < 0.05).
Conclusion: We found that pregabalin had no effect on the choroid, while it had a thinning effect for retinal nerve fiber layer. It is recommended not to be preferred pregabalin in fibromyalgia patients with retinal nerve fiber layer damage such as diabetic retinopathy and glaucoma. Patients treated with pregabalin should have regular control in the ophthalmology clinic.
(© 2021. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.)
Databáze: MEDLINE
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