Protective actions of vitamin D, anandamide and melatonin during vascular inflammation: Epigenetic mechanisms involved.

Autor: Martín Giménez VM; Instituto de Investigaciones en Ciencias Químicas, Facultad de Ciencias Químicas y Tecnológicas, Universidad Católica de Cuyo, Sede San Juan, Argentina., Chuffa LGA; Department of Structural and Functional Biology, UNESP-São Paulo State University, Institute of Biosciences, Botucatu 18618-689, São Paulo, Brazil., Simão VA; Department of Structural and Functional Biology, UNESP-São Paulo State University, Institute of Biosciences, Botucatu 18618-689, São Paulo, Brazil., Reiter RJ; Department of Cell Systems and Anatomy, UT Health, San Antonio, TX, USA., Manucha W; Laboratorio de Farmacología Experimental Básica y Traslacional. Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina; Instituto de Medicina y Biología Experimental de Cuyo, Consejo Nacional de Investigación Científica y Tecnológica (IMBECU-CONICET), Argentina. Electronic address: wmanucha@fcm.uncu.edu.ar.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2022 Jan 01; Vol. 288, pp. 120191. Date of Electronic Publication: 2021 Nov 29.
DOI: 10.1016/j.lfs.2021.120191
Abstrakt: Vascular inflammation is one of the main activating stimuli of cardiovascular disease and its uncontrolled development may worsen the progression and prognosis of these pathologies. Therefore, the search for new therapeutic options to treat this condition is undoubtedly needed. In this regard, it may be better to repurpose endogenous anti-inflammatory compounds already known, in addition to synthesizing new compounds for therapeutic purposes. It is well known that vitamin D, anandamide, and melatonin are promising endogenous substances with powerful and wide-spread anti-inflammatory properties. Currently, the epigenetic mechanisms underlying these effects are often unknown. This review summarizes the potential epigenetic mechanisms by which vitamin D, anandamide, and melatonin attenuate vascular inflammation. This information could contribute to the improvement in the therapeutic management of multiple pathologies associated with blood vessel inflammation, through the pharmacological manipulation of new target sites that until now have not been addressed.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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