| Autor: |
Martins D; Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Tonon CR; Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Pacca RL; Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Matchil NL; Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Junior LAJ; Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Queiroz DS; Department of Orthopedics and Traumatology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Pereira FWL; Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Silva AM; Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Padovese V; Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Padovani de Toledo Moraes M; Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Luiz da Silva D; Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Cardoso Nóbrega V; Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Curcelli EC; Department of Orthopedics and Traumatology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil., Okoshi MP; Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, SP, Brazil. |
| Abstrakt: |
BACKGROUND Gout is a chronic disease characterized by deposition of monosodium urate crystals, typically manifesting as arthritis. Clinical presentation of gout usually results from activation of local inflammatory response. Despite being one of the oldest diseases in the world, gout pathophysiology is incompletely understood and clinical features are still surprising. Recent reports describe unusual manifestations including atypical joints involvement, tenosynovitis, panniculitis, and multinodular inguinal swelling. Another atypical feature is the acute polyarticular gout with severe systemic inflammatory response. CASE REPORT We report the case of a 55-year-old man presenting with fever, tachycardia, cauda equina syndrome, left-knee arthritis, and systemic inflammatory manifestations. Lumbar spine magnetic resonance imaging showed a 4.0×1.3×2.2 cm calcified mass inside the vertebral canal at the L4-L5 level, causing stenosis of the dural space and intervertebral foramen. Clinical diagnoses were septic knee arthritis and lumbar spine meningioma. Despite antibiotic therapy and left-knee surgical drainage, fever and increased C-reactive protein persisted, and arthritis developed in the elbows and right knee. As cultures were negatives, we then diagnosed gout flare in the affected joints accompanied by a severe systemic inflammatory reaction. A few days after starting colchicine and anti-inflammatory drugs, symptoms and inflammatory markers subsided. It was such a severe attack that we called it a "gout storm". CONCLUSIONS The report highlights the difficulty in diagnosing acute polyarticular gout affecting atypical joints, particularly when faced with a severe systemic inflammatory reaction. |
