Photodynamic therapy for squamous cell carcinoma of the head and neck: narrative review focusing on photosensitizers.

Autor: Ibarra AMC; Biophotonics Applied to Health Sciences, Nove de Julho University, UNINOVE, Rua Vergueiro, 235/249 - Liberdade, São Paulo, SP, 01504-001, Brazil., Cecatto RB; School of Medicine, Nove de Julho University, UNINOVE, São Paulo, Brazil.; Rehabilitation Service of the Instituto do Câncer do Estado de São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil., Motta LJ; Biophotonics Applied to Health Sciences, Nove de Julho University, UNINOVE, Rua Vergueiro, 235/249 - Liberdade, São Paulo, SP, 01504-001, Brazil., Dos Santos Franco AL; Biophotonics Applied to Health Sciences, Nove de Julho University, UNINOVE, Rua Vergueiro, 235/249 - Liberdade, São Paulo, SP, 01504-001, Brazil., de Fátima Teixeira da Silva D; Biophotonics Applied to Health Sciences, Nove de Julho University, UNINOVE, Rua Vergueiro, 235/249 - Liberdade, São Paulo, SP, 01504-001, Brazil., Nunes FD; Department of Stomatology, School of Dentistry, University of São Paulo, Av. Professor Lineu Prestes, 2227, Cidade Universitária, São Paulo, 05508-000, Brazil., Hamblin MR; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa.; Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran., Rodrigues MFSD; Biophotonics Applied to Health Sciences, Nove de Julho University, UNINOVE, Rua Vergueiro, 235/249 - Liberdade, São Paulo, SP, 01504-001, Brazil. fernandadestrorodrigues@gmail.com.
Jazyk: angličtina
Zdroj: Lasers in medical science [Lasers Med Sci] 2022 Apr; Vol. 37 (3), pp. 1441-1470. Date of Electronic Publication: 2021 Dec 02.
DOI: 10.1007/s10103-021-03462-3
Abstrakt: This narrative review aimed to evaluate the effectiveness of PDT in early or advanced squamous cell carcinoma of the head and neck (SCCHN). Scopus, MEDLINE/PubMed, and Embase were searched electronically following the PRISMA protocol. Quality assessment was performed according to JBI, NIH, and AMSTAR protocols. The main outcomes evaluated were treatment response, recurrence, survival, and adverse effects. A total of 49 articles met the search criteria: 43 case series, two cohort studies, two prospective before-after clinical trials, one systematic review, and one meta-analysis. Data from 2121 SCCHN patients were included. The response to PDT was variable according to the type of photosensitizer, tumor location, and tumor stage. In general, higher complete responses rated were observed in T1/T2 SCCHN, mainly with mTHPC-mediated PDT. With regard to T3/T4 or advanced SCCHN tumors, there is no compelling evidence suggesting the effectiveness of PDT. Any adverse effects reported were well tolerated by patients. The present review suggests that PDT is a promising treatment modality for early-stage SCCHN. Although there are limitations due to the low level of evidence of the included studies, we believe that the present review could help to design robust clinical trials to determine the efficacy of PDT in SCCHN.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)
Databáze: MEDLINE
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