Worldwide prevalence of microbial agents' coinfection among COVID-19 patients: A comprehensive updated systematic review and meta-analysis.

Autor: Pakzad R; Department of Epidemiology, Faculty of Health, Ilam University Medical Sciences, Ilam, Iran., Malekifar P; Department of Epidemiology, School of Public Health, Tehran University Medical Sciences, Tehran, Iran., Shateri Z; Student research committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Zandi M; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran., Akhavan Rezayat S; Department of Management & Health Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran., Soleymani M; Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Karimi MR; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran., Ahmadi SE; Department of Hematology and Blood Banking, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran., Shahbahrami R; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran., Pakzad I; Department of Microbiology, School of Medicine, Ilam University Medical Sciences, Ilam, Iran., Abdi F; Non-communicable Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran., Farahani A; Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran., Soltani S; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran., Kesheh MM; Department of Virology, School of Medicine, Iran University of Medical Science, Tehran, Iran., Hosseini P; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Journal of clinical laboratory analysis [J Clin Lab Anal] 2022 Jan; Vol. 36 (1), pp. e24151. Date of Electronic Publication: 2021 Dec 01.
DOI: 10.1002/jcla.24151
Abstrakt: Background: To provide information about pathogens' coinfection prevalence with SARS-CoV-2 could be a real help to save patients' lives. This study aims to evaluate the pathogens' coinfection prevalence among COVID-19 patients.
Method: In order to find all of the relevant articles, we used systematic search approach. Research-based databases including PubMed, Web of Science, Embase, and Scopus, without language restrictions, were searched to identify the relevant bacterial, fungal, and viral coinfections among COVID-19 cases from December 1, 2019, to August 23, 2021. In order to dig deeper, other scientific repositories such as Medrxiv were probed.
Results: A total of 13,023 studies were found through systematic search. After thorough analysis, only 64 studies with 61,547 patients were included in the study. The most common causative agents of coinfection among COVID-19 patients were bacteria (pooled prevalence: 20.97%; 95% CI: 15.95-26.46; I 2 : 99.9%) and less frequent were virus coinfections (pooled prevalence: 12.58%; 95% CI: 7.31-18.96; I 2 : 98.7%). The pooled prevalence of fungal coinfections was also 12.60% (95% CI: 7.84-17.36; I 2 : 98.3%). Meta-regression analysis showed that the age sample size and WHO geographic region did not influenced heterogeneity.
Conclusion: We identified a high prevalence of pathogenic microorganism coinfection among COVID-19 patients. Because of this rate of coinfection empirical use of antibacterial, antifungal, and antiviral treatment are advisable specifically at the early stage of COVID-19 infection. We also suggest running simultaneously diagnostic tests to identify other microbiological agents' coinfection with SARS-CoV-2.
(© 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: