Case Report: First Confirmed Case of Coinfection of SARS-CoV-2 With Choclo orthohantavirus .

Autor:	Hesse S; Intensive Care Unit, Luis 'Chicho' Fabrega Hospital, Ministry of Health, Santiago, Panama., Nuñez H; Department of Epidemiology, National Social Security Fund, Santiago, Panama.; Department of Epidemiology, Ezequiel Abadia Hospital, Soná, Panama., Salazar JR; Department of Research in Emerging and Zoonotic Infectious Diseases, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Salinas TP; Department of Research in Emerging and Zoonotic Infectious Diseases, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Barrera E; Intensive Care Unit, Luis 'Chicho' Fabrega Hospital, Ministry of Health, Santiago, Panama., Chong R; Regional Department of Epidemiology, Ministry of Health, Santiago, Panama., Torres S; Department of Epidemiology, Ezequiel Abadia Hospital, Soná, Panama., Cumbrera A; Intensive Care Unit, Luis 'Chicho' Fabrega Hospital, Ministry of Health, Santiago, Panama., Olivares I; Intensive Care Unit, Luis 'Chicho' Fabrega Hospital, Ministry of Health, Santiago, Panama., Junco A; Intensive Care Unit, Luis 'Chicho' Fabrega Hospital, Ministry of Health, Santiago, Panama., Matteo C; Intensive Care Unit, Luis 'Chicho' Fabrega Hospital, Ministry of Health, Santiago, Panama., González C; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Chavarría O; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Moreno A; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Góndola J; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Ábrego L; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute for Health Studies, Panama City, Panama.; National Research System (SNI), National Secretary of Research, Technology and Innovation (SENACYT), Panama City, Panama., Díaz Y; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Pitti Y; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Franco D; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Martínez-Montero M; Inmunovirology Section, Central Reference Laboratory in Public Health, Gorgas Memorial Institute for Health Studies, Panama City, Panama., Pascale JM; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama.; National Research System (SNI), National Secretary of Research, Technology and Innovation (SENACYT), Panama City, Panama., López-Vergès S; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute for Health Studies, Panama City, Panama.; National Research System (SNI), National Secretary of Research, Technology and Innovation (SENACYT), Panama City, Panama., Martínez AA; Department of Genomics and Proteomics, Gorgas Memorial Institute for Health Studies, Panama City, Panama.; National Research System (SNI), National Secretary of Research, Technology and Innovation (SENACYT), Panama City, Panama., Armién B; Department of Research in Emerging and Zoonotic Infectious Diseases, Gorgas Memorial Institute for Health Studies, Panama City, Panama.; National Research System (SNI), National Secretary of Research, Technology and Innovation (SENACYT), Panama City, Panama.
Jazyk:	angličtina
Zdroj:	Frontiers in tropical diseases [Front Trop Dis] 2021 Nov 10; Vol. 2, pp. 769330. Date of Electronic Publication: 2021 Nov 10 (Print Publication: 2021).
DOI:	10.3389/fitd.2021.769330
Abstrakt:	The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a major international public health concern. The World Health Organization (WHO) declared the pandemic of coronavirus disease 2019 (COVID-19) on March 11, 2020. In Panama, the first SARS-CoV-2 infection was confirmed on March 9, 2020, and the first fatal case associated to COVID-19 was reported on March 10. This report presents the case of a 44-year-old female who arrived at the hospital with a respiratory failure, five days after the first fatal COVID-19 case, and who was living in a region where hantavirus pulmonary syndrome cases caused by Choclo orthohantavirus (CHOV), are prevalent. Thus, the clinical personnel set a differential diagnosis to determine a respiratory disease caused by the endemic CHOV or the new pandemic SARS-CoV-2. This case investigation describes the first coinfection by SARS-CoV-2 and CHOV worldwide. PCR detected both viruses during early stages of the disease and the genomic sequences were obtained. The presence of antibodies was determined during the patient's hospitalization. After 23 days at the intensive care unit, the patient survived with no sequelae, and antibodies against CHOV and SARS-CoV-2 were still detectable 12 months after the disease. The detection of the coinfection in this patient highlights the importance, during a pandemic, of complementing the testing and diagnosis of the emergent agent, SARS-CoV-2, with other common endemic respiratory pathogens and other zoonotic pathogens, like CHOV, in regions where they are of public health concern. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Hesse, Nuñez, Salazar, Salinas, Barrera, Chong, Torres, Cumbrera, Olivares, Junco, Matteo, González, Chavarría, Moreno, Góndola, Ábrego, Díaz, Pitti, Franco, Martínez-Montero, Pascale, López-Vergès, Martínez and Armién.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu