Tributyltin and the Female Hypothalamic-Pituitary-Gonadal Disruption.

Autor:	Barbosa KL; Department of Morphology, Federal University of Espirito Santo, Brazil., Dettogni RS; Department of Morphology, Federal University of Espirito Santo, Brazil., da Costa CS; Department of Morphology, Federal University of Espirito Santo, Brazil., Gastal EL; Animal Science, School of Agricultural Sciences, Southern Illinois University, Carbondale, Illinois, USA., Raetzman LT; Department of Molecular and Integrative Physiology., Flaws JA; Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA., Graceli JB; Department of Morphology, Federal University of Espirito Santo, Brazil.
Jazyk:	angličtina
Zdroj:	Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2022 Mar 28; Vol. 186 (2), pp. 179-189.
DOI:	10.1093/toxsci/kfab141
Abstrakt:	The hypothalamic-pituitary-gonadal (HPG) axis is the principal modulator of reproductive function. Proper control of this system relies on several hormonal pathways, which make the female reproductive components susceptible to disruption by endocrine-disrupting chemicals such as tributyltin (TBT). Here, we review the relevant research on the associations between TBT exposure and dysfunction of the female HPG axis components. Specifically, TBT reduced hypothalamic gonadotropin-releasing hormone (GnRH) expression and gonadotropin release, and impaired ovarian folliculogenesis, steroidogenesis, and ovulation, at least in part, by causing abnormal sensitivity to steroid feedback mechanisms and deleterious ovarian effects. This review covers studies using environmentally relevant doses of TBT in vitro (1 ng-20 ng/ml) and in vivo (10 ng-20 mg/kg) in mammals. The review also includes discussion of important gaps in the literature and suggests new avenue of research to evaluate the possible mechanisms underlying TBT-induced toxicity in the HPG axis. Overall, the evidence indicates that TBT exposure is associated with toxicity to the components of the female reproductive axis. Further studies are needed to better elucidate the mechanisms through which TBT impairs the ability of the HPG axis to control reproduction. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu