Research Recommendations Following the Discovery of Pain Sensitizing IgG Autoantibodies in Fibromyalgia Syndrome.

Autor:	Goebel A; Institute of Life Course and Medicine Sciences, Pain Research Institute, University of Liverpool, and Walton Centre NHS Foundation Trust, Liverpool, UK., Andersson D; Institute of Psychiatry, Psychology and Neuroscience, Wolfson Centre for Age Related Disease, King's College, London, UK., Barker C; Lancashire and South Cumbria NHS Foundation Trust, UK., Basu N; Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK., Bullock C; Versus Arthritis, Copeman House, St Mary's Court, St Mary's Gate, Chesterfield, UK., Bevan S; Institute of Psychiatry, Psychology and Neuroscience, Wolfson Centre for Age Related Disease, King's College, London, UK., Bashford-Rogers RJM; Wellcome Centre for Human Genetics, Oxford, UK., Choy E; CREATE Centre, Division of Infection and Immunity, Cardiff University, UK., Clauw D; Anesthesiology, Medicine (Rheumatology) and Psychiatry University of Michigan, Ann Arbor, Michigan, USA., Dulake D; Patient Representative, Relative, Mansfield, UK., Dulake R; Patient Representative, Relative, Mansfield, UK., Flor H; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Glanvill M; Patient Representative, Liverpool, UK., Helyes Z; Department of Pharmacology and Pharmacotherapy, Medical School & Szentágothai Research Centre, University of Pécs, Pécs, Hungary., Irani S; Oxford Autoimmune Neurology Group, John Radcliffe Hospital, University of Oxford, Oxford, UK., Kosek E; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Laird J; Eli Lilly and Company, Pain & Neurodegeneration Therapeutic Area, Lilly Research Centre, Windlesham, Surrey, UK., MacFarlane G; Epidemiology Group, Aberdeen, Scotland., McCullough H; Institute of Life Course and Medicine Sciences, Pain Research Institute, University of Liverpool, Liverpool, UK., Marshall A; Institute of Life Course and Medicine Sciences, Pain Research Institute, University of Liverpool, and Walton Centre NHS Foundation Trust, Liverpool, UK., Moots R; Faculty of Health Social Care and Medicine, Edge Hill University, Liverpool, UK.; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Perrot S; Pain Center, Cochin Hospital, Paris University, Paris, France., Shenker N; Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK., Sher E; Eli Lilly and Company, Pain & Neurodegeneration Therapeutic Area, Lilly Research Centre, Windlesham, Surrey, UK., Sommer C; Department of Neurology, University Hospital Würzburg, Germany., Svensson CI; Department of Physiology and Pharmacology, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden., Williams A; Health Psychology, UCL Research Department of Clinical, Educational & Health Psychology, University College London, UK., Wood G; Cambridge Institute for Medical Research, Cambridge, UK., Dorris ER; School of Medicine, University College Dublin, Ireland.
Jazyk:	angličtina
Zdroj:	Pain medicine (Malden, Mass.) [Pain Med] 2022 May 30; Vol. 23 (6), pp. 1084-1094.
DOI:	10.1093/pm/pnab338
Abstrakt:	Background: Fibromyalgia syndrome (FMS) is the most common chronic widespread pain condition in rheumatology. Until recently, no clear pathophysiological mechanism for fibromyalgia had been established, resulting in management challenges. Recent research has indicated that serum immunoglobulin Gs (IgGs) may play a role in FMS. We undertook a research prioritisation exercise to identify the most pertinent research approaches that may lead to clinically implementable outputs. Methods: Research priority setting was conducted in five phases: situation analysis; design; expert group consultation; interim recommendations; consultation and revision. A dialogue model was used, and an international multi-stakeholder expert group was invited. Clinical, patient, industry, funder, and scientific expertise was represented throughout. Recommendation-consensus was determined via a voluntary closed eSurvey. Reporting guideline for priority setting of health research were employed to support implementation and maximise impact. Results: Arising from the expert group consultation (n = 29 participants), 39 interim recommendations were defined. A response rate of 81.5% was achieved in the consensus survey. Six recommendations were identified as high priority- and 15 as medium level priority. The recommendations range from aspects of fibromyalgia features that should be considered in future autoantibody research, to specific immunological investigations, suggestions for trial design in FMS, and therapeutic interventions that should be assessed in trials. Conclusions: By applying the principles of strategic priority setting we directed research towards that which is implementable, thereby expediating the benefit to the FMS patient population. These recommendations are intended for patients, international professionals and grant-giving bodies concerned with research into causes and management of patients with fibromyalgia syndrome. (© The Author(s) 2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine.)
Databáze:	MEDLINE
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