Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjögren's syndrome: an OMERACT reliability exercise.

Autor:	Hočevar A; Department of Rheumatology, University Medical Centre, Ljubljana, Slovenia., Bruyn GA; Department of Rheumatology, MC Groep Hospitals, Lelystad, The Netherlands., Terslev L; Centre for Rheumatology and Spinal Diseases, Rigshospitalet, Copenhagen, Denmark., De Agustin JJ; Department of Rheumatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain., MacCarter D; Rheumatology Department, North Valley Hospital, Whitefish, MT, USA., Chrysidis S; Department of Rheumatology, Hospital of Southwest Jutland, Esbjerg, Denmark., Collado P; Universitario Severo Ochoa, Madrid, Spain., Dejaco C; Department of Rheumatology, Medical University Graz, Graz, Austria., Fana V; Department of Rheumatology, Hospital of Bruneck (ASAA-SABES)., Filippou G; Section of Rheumatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Finzel S; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Gandjbakhch F; Sorbonne Université.; Rheumatology Department, Pitié Salpêtrière Hospital, APHP, Paris, France., Hanova P; Institute of Rheumatology, Prague, Czech Republic., Hammenfors D; Department of Rheumatology, Haukeland University Hospital, Bergen, Norway., Hernandez-Diaz C; Musculoskeletal Ultrasound Laboratory, Instituto Nacional de Rehabilitacion, Mexico City, Mexico., Iagnocco A; Academic Rheumatology Centre, Università degli Studi di Torino, Turin, Italy., Mortada MA; Rheumatology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Inanc N; Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey., Naredo E; Rheumatology Department, Joint and Bone Research Unit, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain., Ohrndorf S; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany., Perko N; Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia., Schmidt WA; Medical Centre for Rheumatology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany., Tamborrini G; UZR-Ultraschallzentrum Rheumatologie, Basel, Switzerland., Tomšič M; Department of Rheumatology, University Medical Centre, Ljubljana, Slovenia., Chary-Valckenaere I; Department of Rheumatology, University Hospital of Nancy, Nancy, France., Zabotti A; Department of Medical and Biological Sciences, Rheumatology Institute, University Hospital Santa Maria della Misericordia, Udine, Italy., Keen HI; Rheumatology Department, Royal Perth Hospital, Perth, WA, Australia., Pineda C; Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico., D'Agostino MA; Department of Rheumatology, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli, Rome, Italy.; Paris Saclay University of Versailles Saint Quentin en Yvelines, UMRII73., Jousse-Joulin S; Rheumatology Department, Chu de Brest, University of Brest, INSERM, Brest, France.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 Aug 03; Vol. 61 (8), pp. 3341-3350.
DOI:	10.1093/rheumatology/keab876
Abstrakt:	Objective: The aim of this exercise from the OMERACT Ultrasound subgroup on Sjögren's syndrome was to develop and assess the reliability of a consensus-based semiquantitative colour Doppler US scoring system for pathologic salivary gland vascularization in patients with primary Sjögren's syndrome (pSS). Methods: Using the Delphi method, a colour Doppler semiquantitative scoring system for vascularization of bilateral parotid and submandibular glands was developed and tested in static images and on patients (9 pSS patients and 9 sonographers). Intra-reader and inter-reader reliability of grading the salivary glands were computed by weighted Cohen and Light's kappa analysis, respectively. Results: The consensus-based semiquantitative score was: grade 0, no visible vascular signals; grade 1, focal, dispersed vascular signals; grade 2, diffuse vascular signals detected in <50% of the gland; grade 3, diffuse vascular signals in >50% of the gland. In static images, the intra- and inter-reader reliability showed excellent kappa values (95% CI) of 0.90 (0.87, 0.93) and 0.80 (0.74, 0.84), respectively, for all four salivary glands together. In patients, the intra- and inter-reader reliability for all four salivary glands together was kappa = 0.84 (0.73, 0.92) and 0.70 (0.64, 0.76), respectively. Conclusion: The consensus-based colour Doppler US scoring for the evaluation of salivary gland vascularization in pSS showed a good inter-reader reliability and excellent intra-reader reliability in static images and in patients. The clinical application of the developed scoring system should be tested in clinical settings. (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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