Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats.

Autor: Youssef ME; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology Gamasa, Talkha, Egypt., El-Azab MF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt., Abdel-Dayem MA; Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Horus University, New Damietta, Egypt., Yahya G; Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Al Sharqia, 44519, Egypt. galalmetwally2020@gmail.com., Alanazi IS; Department of Biology, Faculty of Sciences, University of Hafr Al Batin, Hafr Al Batin, Saudi Arabia., Saber S; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology Gamasa, Talkha, Egypt.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2022 Apr; Vol. 29 (17), pp. 25723-25732. Date of Electronic Publication: 2021 Nov 30.
DOI: 10.1007/s11356-021-17831-6
Abstrakt: Diabetes is a clinical condition that is associated with insulin deficiency and hyperglycemia. Cardiomyopathy, retinopathy, neuropathy, and nephropathy are well known complications of the elevated blood glucose. Diabetic cardiomyopathy is a clinical disorder that is associated with systolic and diastolic dysfunction along with cardiac fibrosis, inflammation, and elevated oxidative stress. In this study, diabetes was induced by intraperitoneal injection of streptozotocin (STZ) 50 mg/kg. We determined the plasma levels of cardiac troponin-T (cTnT) and creatinine kinase MB (CK-MB) by ELISA. Diabetic rats showed abnormal cardiac architecture and increased collagen production. Significant elevation in ST-segment, prolonged QRS, and QT-intervals and increased ventricular rate were detected. Additionally, diabetic rats showed a prolongation in P wave duration and atrial tachyarrhythmia was observed. Plasma levels of cTnT and CK-MB were elevated. In conclusion, these electrocardiographic changes (elevated ST-segment, prolonged QT interval, and QRS complex, and increased heart rate) along with histopathological changes and increased collagen formation could be markers for the development of diabetic cardiomyopathy in rats.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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