Cerebrospinal fluid biomarkers in Parkinson's disease with freezing of gait: an exploratory analysis.

Autor:	Hatcher-Martin JM; Jean & Paul Amos PD & Movement Disorders Program, Department of Neurology, Emory University, Atlanta, GA, USA.; Department of Neurology, SOC Telemed, Atlanta, GA, USA., McKay JL; Jean & Paul Amos PD & Movement Disorders Program, Department of Neurology, Emory University, Atlanta, GA, USA.; Department of Biomedical Informatics, Emory University, Atlanta, GA, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, USA., Pybus AF; Department of Mechanical Engineering, Georgia Tech, Atlanta, GA, USA., Sommerfeld B; Jean & Paul Amos PD & Movement Disorders Program, Department of Neurology, Emory University, Atlanta, GA, USA., Howell JC; Neurology Consultants of Dallas, Dallas, TX, USA., Goldstein FC; Neuropsychology Program, Department of Neurology, Emory University, Atlanta, GA, USA., Wood L; Department of Mechanical Engineering, Georgia Tech, Atlanta, GA, USA., Hu WT; Alzheimer's Disease Research Center, Emory University and Cognitive Neurology Division, Rutgers-Robert Wood Johnson Medical School and Institute for Health, Health Care Policy, and Aging Research, Atlanta, GA, USA., Factor SA; Jean & Paul Amos PD & Movement Disorders Program, Department of Neurology, Emory University, Atlanta, GA, USA. sfactor@emory.edu.
Jazyk:	angličtina
Zdroj:	NPJ Parkinson's disease [NPJ Parkinsons Dis] 2021 Nov 29; Vol. 7 (1), pp. 105. Date of Electronic Publication: 2021 Nov 29.
DOI:	10.1038/s41531-021-00247-x
Abstrakt:	We explore the association between three Alzheimer's disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson's disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and healthy controls (HC, N = 12). Age and PD duration are not significantly different between groups. After adjusting for covariates and multiple comparisons, the anti-inflammatory marker, fractalkine, is significantly decreased in the PD groups compared to HC (P = 0.002), and further decreased in PD-FOG compared to PD-NoFOG (P = 0.007). The Alzheimer's disease-related protein, Aβ42, is increased in PD-FOG compared to PD-NoFOG and HC (P = 0.001). Group differences obtained in individual biomarker analyses are confirmed with multivariate discriminant partial least squares regression (P < 0.001). High levels of Aβ42 in PD-FOG patients supports an increase over time from early to advanced state. Low levels of fractalkine might suggest anti-inflammatory effect. These findings warrant replication. (© 2021. The Author(s).)
Databáze:	MEDLINE
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