Prevalence of respiratory epithelial adenomatoid hamartomas (REAH) associated with nasal polyposis: an epidemiological study - how to diagnose.

Autor:	Issa MJA; Universidade Federal de Minas Gerais (UFMG), Programa de Otorrinolaringologia, Belo Horizonte, MG, Brazil., Oliveira VRR; Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Nunes FB; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Otorrinolaringologia, Belo Horizonte, MG, Brazil., Vasconcelos LOG; Núcleo de Otorrino BH, Belo Horizonte, MG, Brazil., Souza LFB; Universidade Federal de Minas Gerais (UFMG), Hospital Universitário, Belo Horizonte, MG, Brazil., Cherobin GB; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Otorrinolaringologia, Belo Horizonte, MG, Brazil., Guimarães RES; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Otorrinolaringologia, Belo Horizonte, MG, Brazil; Universidade de São Paulo, Ribeirão Preto, SP, Brazil; Academia de Medicina de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: resguimaraes@gmail.com.
Jazyk:	angličtina
Zdroj:	Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2022 Nov-Dec; Vol. 88 Suppl 5, pp. S57-S62. Date of Electronic Publication: 2021 Nov 10.
DOI:	10.1016/j.bjorl.2021.09.009
Abstrakt:	Objectives: To highlight the prevalence of respiratory epithelial adenomatoid hamartomas in the olfactory cleft of patients with nasal polyposis. To demonstrate characteristics indicative of hamartoma on the CT scans of paranasal sinuses during surgery and in histopathological exams. Methods: Cross-sectional study carried out in Hospital das Clínicas da UFMG and Núcleo de Otorrino BH. We performed 114 nasal endoscopic surgeries for polyposis, between February 2015 and November 2019. We assessed the olfactory cleft width in all preoperative CT scans. Upon seeing an indication of hamartoma on the CT scan, we took a tissue sample from the olfactory cleft during the surgery and sent for histopathological exam. We referred the samples to a pathologist experienced in the anatomopathological diagnosis of respiratory epithelial adenomatoid hamartomas. Results: Of the 114 patients with polyposis, 54 (47.4%) had olfactory cleft enlargement and, 100% of them had tissue with a dense and hardened polypoid aspect, with a slight cerebriform appearance in this region during the surgery. Histology confirmed a respiratory epithelial adenomatoid hamartoma. Conclusion: This observation suggests that the presence of hamartomas in polyposis is common, but underdiagnosed. Level of Evidence: Step 3 (Level 3). (Copyright © 2021 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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