Study of the pharmacokinetics of various drugs under conditions of antiorthostatic hypokinesia and the pharmacokinetics of acetaminophen under long-term spaceflight conditions.

Autor:	Polyakov AV; Laboratory for the Development of Means and Methods of Medical Care in Extreme Conditions and Telemedicine of the State Scientific Centre of the Russian Federation, Institute of Medical and Biological Problems of the Russian Academy of Sciences, Moscow, Russian Federation., Svistunov AA; Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russian Federation., Kondratenko SN; Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russian Federation., Kovachevich IV; Laboratory for the Development of Means and Methods of Medical Care in Extreme Conditions and Telemedicine of the State Scientific Centre of the Russian Federation, Institute of Medical and Biological Problems of the Russian Academy of Sciences, Moscow, Russian Federation., Repenkova LG; Laboratory for the Development of Means and Methods of Medical Care in Extreme Conditions and Telemedicine of the State Scientific Centre of the Russian Federation, Institute of Medical and Biological Problems of the Russian Academy of Sciences, Moscow, Russian Federation., Savelyeva MI; Department of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russian Federation., Shikh EV; Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russian Federation., Badriddinova LY; Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russian Federation.
Jazyk:	angličtina
Zdroj:	Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2021 Nov 29. Date of Electronic Publication: 2021 Nov 29.
DOI:	10.1515/dmdi-2021-0159
Abstrakt:	Objectives: To study the pharmacokinetics and relative bioavailability of drugs of different chemical structure and pharmacological action under conditions simulating the effects of some factors of spaceflight, as well as the peculiarities of the pharmacokinetics of acetaminophen under long-term spaceflight conditions. Methods: The pharmacokinetics of verapamil (n=8), propranolol (n=8), etacizine (n=9), furosemide (n=6), and acetaminophen (n=7) in healthy volunteers after a single oral administration under normal conditions (background) and under antiorthostatic hypokinesia (ANOH), the pharmacokinetics of acetaminophen in spaceflight members under normal ground conditions (background) (n=8) and under prolonged spaceflight conditions (SF) (n=5) were studied. Results: The stay of volunteers under antiorthostatic hypokinesia had different effects on the pharmacokinetics and bioavailability of drugs: Compared to background, there was a decreasing trend in V z for verapamil (-54 Δ%), furosemide (-20 Δ%), propranolol (-8 Δ%), and acetaminophen (-9 Δ%), but a statistically significant increase in V z was found for etacizine (+39 Δ%); there was an increasing trend in Cl t for propranolol (+13 Δ%) and acetaminophen (+16 Δ%), and a decreasing trend in Cl t for etacizine, verapamil, and furosemide (-22, -23 and -9 Δ% respectively) in ANOH. The relative bioavailability of etacizine, verapamil, and furosemide in ANOH increased compared to background (+40, +23 and +13 Δ%, respectively), propranolol and acetaminophen decreased (-5 and -12 Δ% accordingly). The relative rate of absorption of etacizine and furosemide in ANOH decreased (-19 and -20 Δ%, respectively) while that of verapamil, propranolol, and acetaminophen increased (+42, +58 and +26 Δ%, respectively). A statistically significant decrease in AUC 0-∞ (-57 Δ%), C max (-53 Δ%), relative bioavailability of acetaminophen (-52 Δ%) and a sharp increase in Cl t (+147 Δ%), T max (+131 Δ%) as well as a trend towards a significant decrease in T 1/2 (-53 Δ%), MRT (-36 Δ%) and a moderate increase in V z (+24 Δ%) were found under control compared to background. Unidirectional changes in AUC 0-∞ , Cl t , T 1/2 , MRT and relative bioavailability of acetaminophen, which are more pronounced in SF and opposite dynamics for C max , T max , V z were found in ANOH and SP compared to background studies. Conclusions: The data obtained allow recommending the studied drugs for rational pharmacotherapy in the possible development of cardiovascular disease in manned spaceflight. (© 2021 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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