Passive exposure to cannabidiol oil does not cause microbiome dysbiosis in larval zebrafish.

Autor:	Talamantes M; Department of Biology, Reem-Kayden Center for Science and Computation, Bard College, Annandale-On-Hudson, NY, USA., Schneeberg SR; Department of Chemistry, Reem-Kayden Center for Science and Computation, Bard College, Annandale-On-Hudson, NY, USA., Pinto A; Department of Chemistry, Reem-Kayden Center for Science and Computation, Bard College, Annandale-On-Hudson, NY, USA., Perron GG; Department of Biology, Reem-Kayden Center for Science and Computation, Bard College, Annandale-On-Hudson, NY, USA.; Bard Food Lab, Center for Experimental Humanities, Bard College, Annandale-On-Hudson, NY, USA.
Jazyk:	angličtina
Zdroj:	Current research in microbial sciences [Curr Res Microb Sci] 2021 Jun 21; Vol. 2, pp. 100045. Date of Electronic Publication: 2021 Jun 21 (Print Publication: 2021).
DOI:	10.1016/j.crmicr.2021.100045
Abstrakt:	The use of cannabidiol oil derived products has dramatically increased in popularity and is predicted to grow steadily over the next decade. Given its relative stability, cannabidiol is likely to accumulate in the environment and affect aquatic animals and their host-associated microbiomes. Here, using zebrafish larvae, a model system in environmental toxicology, we show that passive exposure to a concentration as high as 200 µg/L cannabidiol oil did not affect larvae survival and had limited effects on their host-associated microbial communities. We found that the changes in community structure were limited to a decrease in two sequence variants identified as Methylobacterium - Methylorubrum sp. and one ASV identified as Staphylococcus sp., as well as the increase of one sequence variant identified as Chryseobacterium sp., a bacterium commensal to zebrafish. More importantly, we found that cannabidiol oil did not affect the overall richness and diversity of the exposed fish microbiomes. These results suggest that passive exposure to cannabidiol oil is unlikely to impact aquatic organisms in significant ways. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Authors. Published by Elsevier B.V.)
Databáze:	MEDLINE
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