The Serum Level of Oxidative Stress and Antioxidant Markers in Patients with Psoriasis: A Cross-sectional Study.

Autor:	Shakoei S; Drs. Shakoei and Motlagh are with the Department of Dermatology at Imam Khomeini Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Nakhjavani and Mirmiranpoor are with the Endocrinology and Metabolism Research Center at Vali-Asr Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Azizpour and Abedini are with the Department of Dermatology at Razi Hospital, Tehran University of Medical Sciences in Tehran, Iran., Nakhjavani M; Drs. Shakoei and Motlagh are with the Department of Dermatology at Imam Khomeini Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Nakhjavani and Mirmiranpoor are with the Endocrinology and Metabolism Research Center at Vali-Asr Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Azizpour and Abedini are with the Department of Dermatology at Razi Hospital, Tehran University of Medical Sciences in Tehran, Iran., Mirmiranpoor H; Drs. Shakoei and Motlagh are with the Department of Dermatology at Imam Khomeini Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Nakhjavani and Mirmiranpoor are with the Endocrinology and Metabolism Research Center at Vali-Asr Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Azizpour and Abedini are with the Department of Dermatology at Razi Hospital, Tehran University of Medical Sciences in Tehran, Iran., Motlagh MA; Drs. Shakoei and Motlagh are with the Department of Dermatology at Imam Khomeini Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Nakhjavani and Mirmiranpoor are with the Endocrinology and Metabolism Research Center at Vali-Asr Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Azizpour and Abedini are with the Department of Dermatology at Razi Hospital, Tehran University of Medical Sciences in Tehran, Iran., Azizpour A; Drs. Shakoei and Motlagh are with the Department of Dermatology at Imam Khomeini Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Nakhjavani and Mirmiranpoor are with the Endocrinology and Metabolism Research Center at Vali-Asr Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Azizpour and Abedini are with the Department of Dermatology at Razi Hospital, Tehran University of Medical Sciences in Tehran, Iran., Abedini R; Drs. Shakoei and Motlagh are with the Department of Dermatology at Imam Khomeini Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Nakhjavani and Mirmiranpoor are with the Endocrinology and Metabolism Research Center at Vali-Asr Hospital, Tehran University of Medical Sciences in Tehran, Iran.; Drs. Azizpour and Abedini are with the Department of Dermatology at Razi Hospital, Tehran University of Medical Sciences in Tehran, Iran.
Jazyk:	angličtina
Zdroj:	The Journal of clinical and aesthetic dermatology [J Clin Aesthet Dermatol] 2021 Jul; Vol. 14 (7), pp. 38-41. Date of Electronic Publication: 2021 Jul 01.
Abstrakt:	Background: soriasis is a chronic, immune-mediated, inflammatory disease. Previous studies have indicated a possible role of oxidative stress in the pathogenesis of psoriasis. Objective: We sought to compare special oxidative stress and antioxidant markers in psoriatic patients. Methods: This study included 35 patients with psoriasis and 35 healthy controls. Serum levels of oxidant markers, including advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs), as well as antioxidant enzymes, including lecithin-cholesterol acyltransferase (LCAT), paraoxonase-1 (PON1), and ferric-reducing ability of plasma (FRAP), were measured. Results: The mean age of the subjects was 39.63±13 years in the case group and 39.37±12.62 years in the control group ( p =0.92). The mean Psoriasis Area and Severity Index (PASI) scores of these groups were 15.27 and 10.47. The mean levels of fasting blood sugar and C-reactive protein were significantly higher in the case group than the control group ( p =0.04 and p =0.02, respectively). Moreover, the mean levels of AGEs and AOPPs in the case group were significantly higher than in the control group ( p =0.001), while the mean levels of FRAP, PON1, and LCAT were significantly lower in the case group than in the control group ( p =0.001). There was no significant association between PASI and oxidant or antioxidant markers, except for AOPP, which had a negative association with PASI. Conclusion: Our findings suggest an imbalance among oxidative stress and antioxidant markers in the pathogenesis of psoriasis. The oxidant-antioxidant enzymatic system is impaired in psoriasis as a result of increased oxidant products and reduced antioxidant activity. Competing Interests: DISCLOSURES: The authors report no conflicts of interest relevant to the content of this article. (Copyright © 2021. Matrix Medical Communications. All rights reserved.)
Databáze:	MEDLINE
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