Antinociceptive and analgesic effect of continuous intravenous infusion of maropitant, lidocaine and ketamine alone or in combination in cats undergoing ovariohysterectomy.

Autor: Corrêa JMX; Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Km 16, Rodovia Jorge Amado, Ilhéus, Bahia, CEP- 45662-900, Brazil. janainaxaviercorrea@gmail.com., Niella RV; Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Km 16, Rodovia Jorge Amado, Ilhéus, Bahia, CEP- 45662-900, Brazil., Oliveira JNS; Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Km 16, Rodovia Jorge Amado, Ilhéus, Bahia, CEP- 45662-900, Brazil., Silva Junior AC; Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Km 16, Rodovia Jorge Amado, Ilhéus, Bahia, CEP- 45662-900, Brazil., Marques CSDC; Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Km 16, Rodovia Jorge Amado, Ilhéus, Bahia, CEP- 45662-900, Brazil., Pinto TM; Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Km 16, Rodovia Jorge Amado, Ilhéus, Bahia, CEP- 45662-900, Brazil., Silva EBD; Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Km 16, Rodovia Jorge Amado, Ilhéus, Bahia, CEP- 45662-900, Brazil., Beier SL; School of Veterinary Medicine, Campus Pampulha of Federal University of Minas Gerais, Avenue Antônio Carlos, 6627, mailbox 567, Belo Horizonte, Minas Gerais, Brazil., Silva FL; Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Km 16, Rodovia Jorge Amado, Ilhéus, Bahia, CEP- 45662-900, Brazil., Lavor MSL; Department of Agricultural and Environmental Sciences, State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Km 16, Rodovia Jorge Amado, Ilhéus, Bahia, CEP- 45662-900, Brazil.
Jazyk: angličtina
Zdroj: Acta veterinaria Scandinavica [Acta Vet Scand] 2021 Nov 27; Vol. 63 (1), pp. 49. Date of Electronic Publication: 2021 Nov 27.
DOI: 10.1186/s13028-021-00615-w
Abstrakt: Background: Multimodal analgesia consists of the combination of analgesic drugs at low doses to act in different places along the path of pain. Studies with continuous infusion of analgesic drugs in cats are not common. This study aimed to evaluate the analgesic effect of maropitant, lidocaine and ketamine alone or in combination (intravenous bolus + subsequent continuous intravenous infusion) in the management of acute postoperative pain in cats undergoing ovariohysterectomy. Seventy healthy cats undergoing an ovariohysterectomy received a standard anesthetic protocol consisting of acepromazine and morphine, propofol (anesthesia induction), and isoflurane (anesthesia maintenance). The animals were stratified into seven groups (n = 10 in each group): control (CG), maropitant (MG), lidocaine (LG), ketamine (KG), maropitant + lidocaine (LMG), maropitant + ketamine (KMG), and maropitant + lidocaine + ketamine (LKMG). All drugs were injected first as an intravenous bolus and then by continuous intravenous infusion. During surgery, esophageal temperature, respiratory rate, heart rate, oxygen saturation, expired isoflurane concentration, and partial pressure of carbon dioxide at the end of expiration were evaluated at 7 time points. Postoperative pain was evaluated for 6 h after extubation using the visual analogue scale and the UNESP-Botucatu multidimensional composite pain scale for assessing postoperative pain in cats.
Results: Adverse effects related to maropitant, lidocaine and ketamine infusion were not observed. Pain scores were lower in the MG, KG and LG groups when compared to the CG group using both scales. Although pain scores were also lower in all combination groups than CG, more animals in these groups required rescue analgesia compared to MG. This indicates that the postoperative analgesic effect of all drugs, either alone or in combination, confers analgesia, although the combinations did not promote greater analgesia.
Conclusions: Continuous intravenous infusion of maropitant, lidocaine, and ketamine alone induces postoperative analgesic effect in cats undergoing ovariohysterectomy, but combinations of these drugs did not increase the analgesic effect. No adverse effect was observed with any drug or their combination.
(© 2021. The Author(s).)
Databáze: MEDLINE
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