Depletion of essential fatty acids in muscle is associated with shorter survival of cancer patients undergoing surgery-preliminary report.

Autor: Bhullar AS; Department of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada., Rivas-Serna IM; Department of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada., Anoveros-Barrera A; Department of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada., Dunichand-Hoedl A; Department of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada., Bigam D; Department of Surgery, University of Alberta, Edmonton, Canada., Khadaroo RG; Department of Surgery, University of Alberta, Edmonton, Canada., McMullen T; Department of Surgery, University of Alberta, Edmonton, Canada., Bathe O; Departments of Surgery and Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Canada., Putman CT; Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada.; Department of Oncology, University of Alberta, Edmonton, Canada., Baracos V; Department of Oncology, University of Alberta, Edmonton, Canada., Clandinin MT; Department of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada.; Department of Medicine, University of Alberta, Edmonton, Canada., Mazurak VC; Department of Agricultural, Food & Nutritional Science, University of Alberta, 4-002 Li Ka Shing Centre for Health Research Innovation, 8602-112 St NW, Edmonton, AB, Canada. vera.mazurak@ualberta.ca.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Nov 26; Vol. 11 (1), pp. 23006. Date of Electronic Publication: 2021 Nov 26.
DOI: 10.1038/s41598-021-02269-0
Abstrakt: Emerging studies are reporting associations between skeletal muscle abnormalities and survival in cancer patients. Cancer prognosis is associated with depletion of essential fatty acids in erythrocytes and plasma in humans. However the relationship between skeletal muscle membrane fatty acid composition and survival is unknown. This study investigates the relationship between fatty acid content of phospholipids in skeletal muscle and survival in cancer patients. Rectus abdominis biopsies were collected during cancer surgery from 35 patients diagnosed with cancer. Thin-layer and gas chromatography were used for quantification of phospholipid fatty acids. Cutpoints for survival were defined using optimal stratification. Median survival was between 450 and 500 days when patients had arachidonic acid (AA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in muscle phospholipid below the cut-point compared to 720-800 days for patients above. Cox regression analysis revealed that low amounts of AA, EPA and DHA are risk factors for death. The risk of death remained significant for AA [HR 3.5 (1.11-10.87), p = 0.03], EPA [HR 3.92 (1.1-14.0), p = 0.04] and DHA [HR 4.08 (1.1-14.6), p = 0.03] when adjusted for sex. Lower amounts of essential fatty acids in skeletal muscle membrane is a predictor of survival in cancer patients. These results warrant investigation to restore bioactive fatty acids in people with cancer.
(© 2021. The Author(s).)
Databáze: MEDLINE
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