| Autor: |
Ikram J; College of Pharmacy University of Sargodha, Sargodha, Pakistan., Alamgeer -; College of Pharmacy University of Sargodha, Sargodha, Pakistan/ Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan., Muhammad Irfan H; College of Pharmacy University of Sargodha, Sargodha, Pakistan., Akram M; College of Pharmacy University of Sargodha, Sargodha, Pakistan., Hussain Asim M; College of Pharmacy University of Sargodha, Sargodha, Pakistan., Hadal Alotaibi N; College of Pharmacy, Jouf University, Aljouf, Sakaka, Saudi Arabia., Saad Alharbi K; College of Pharmacy, Jouf University, Aljouf, Sakaka, Saudi Arabia., Abbas Bukhari SN; College of Pharmacy, Jouf University, Aljouf, Sakaka, Saudi Arabia., Qasim S; College of Pharmacy, Jouf University, Aljouf, Sakaka, Saudi Arabia., Niazi ZR; Department of Pharmacology, Faculty of Pharmacy, Gomal University, D I Khan KPK, Pakistan. |
| Abstrakt: |
Eruca sativa, member of family Brassicaceae, was evaluated for its anti-arthritic potential. Both in vitro and in vivo models were used to bring out a safe, effective and economical remedy. In vitro tests included egg albumin denaturation suppression, bovine serum albumin assay and human red blood cells maintenance assay. While in vivo formaldehyde-induced arthritic model was initiated to check effect on paw volume. Similarly, carrageenan produced inflammation was applied to check anti-inflammatory ability of the plant. Acute toxicity studies showed safety margin at 2000mg/kg. The plant showed concentration dependent denaturation protection and membrane stability in vitro assays. Likewise, the carrageenan and formaldehyde investigations revealed visible paw volume reduction in dose attributed manner, with maximum outcome at dose of 500mg/kg. Hence, it may be established on the ground of presented results that ethyl-acetate extract of Eruca sativa has significant anti-inflammatory and anti-arthritic effects and may be considered for further research to reveal the core mechanism. |
