Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study.

Autor:	Estella Á; Intensive Care Unit, Medicine Department University of Cadiz, University Hospital of Jerez, INiBICA, 11001 Jerez, Spain., Cantón ML; Intensive Care Unit, University Hospital Virgen Macarena, 41013 Sevilla, Spain., Muñoz L; Intensive Care Unit, Hospital Costa del Sol de Marbella, 29001 Málaga, Spain., Higueras IR; Intensive Care Unit, University Hospital Torrecárdenas, 04001 Almería, Spain., Recuerda Núñez M; Intensive Care Unit, University Hospital of Jerez, INiBICA, 11001 Jerez, Spain., Tejero Aranguren J; Intensive Care Unit, University Hospital San Cecilio, 18001 Granada, Spain., Zaya B; Intensive Care Unit, Hospital Costa del Sol de Marbella, 29001 Málaga, Spain., Gómez C; Intensive Care Unit, Hospital Costa del Sol de Marbella, 29001 Málaga, Spain., Amaya R; Intensive Care Unit, University Hospital Virgen del Rocío, 41013 Sevilla, Spain., Hurtado Martinez Á; Intensive Care Unit, University Hospital Virgen de Valme, 41013 Sevilla, Spain., Del Valle Odero Bernal M; Intensive Care Unit, University Hospital of Jerez, INiBICA, 11001 Jerez, Spain., De la Fuente C; Intensive Care Unit, University Hospital Reina Sofía, 14004 Córdoba, Spain., Alados JC; Intensive Care Unit, University Hospital of Jerez, INiBICA, 11001 Jerez, Spain., Garnacho-Montero J; Intensive Care Unit, University Hospital Virgen Macarena, 41013 Sevilla, Spain., On Behalf Of The Group Of Infectious Diseases Of The Andalusian Society Of Intensive Care And Coronary Units Samiuc
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2021 Oct 25; Vol. 11 (11). Date of Electronic Publication: 2021 Oct 25.
DOI:	10.3390/jpm11111086
Abstrakt:	Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. Results: Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. Conclusions: Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised.
Databáze:	MEDLINE
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