Characterization of Microbial Degradation Products of Steviol Glycosides.

Autor: Steurs G; Division of Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200f, P.O. Box 2404, 3001 Leuven, Belgium., Moons N; Division of Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200f, P.O. Box 2404, 3001 Leuven, Belgium., Van Meervelt L; Division of Biochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, Celestijnenlaan 200f, P.O. Box 2404, 3001 Leuven, Belgium., Meesschaert B; Laboratory for Microbial and Biochemical Technology, Department of Microbial and Molecular Systems, KU Leuven Bruges Campus, Spoorwegstraat 12, P.O. Box 7913, 8200 Brugge, Belgium., De Borggraeve WM; Division of Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200f, P.O. Box 2404, 3001 Leuven, Belgium.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2021 Nov 16; Vol. 26 (22). Date of Electronic Publication: 2021 Nov 16.
DOI: 10.3390/molecules26226916
Abstrakt: Steviol glycosides were subjected to bacteria present in a soil sample collected from a Stevia plantation in Paraguay. During the incubation experiments, next to the aglycon steviol, steviol degradation products were also formed. X-ray analysis and NMR methods in combination with chemical synthesis and GIAO NMR calculations were used to fully characterize the structure of these compounds as a tricyclic ketone and the corresponding reduced form. They were nicknamed monicanone and monicanol . The latter has the ( S )-configuration at the alcohol site.
Databáze: MEDLINE
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