| Autor: |
Wang L; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Kim HS; National Marine Biodiversity Institute of Korea, 75, Jangsan-ro 101gil, Janghang-eup, Seocheon 33662, Korea., Je JG; Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea., Fu X; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Huang C; Co-Innovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China., Ahn G; Department of Marine Bio Food Science, Chonnam National University, Yeosu 59626, Korea., Oh JY; Food Safety and Processing Research Division, National Institute of Fisheries Science, Busan 46083, Korea., Sanjeewa KKA; Department of Biosystem Technology, Faculty of Technology, University of Sri Jayewardenepura, Pitipana, Homagama 10206, Sri Lanka., Xu J; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Gao X; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China., Yeo IK; Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea., Jeon YJ; Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea.; Marine Science Institute, Jeju National University, Jeju 63333, Korea. |
| Abstrakt: |
Skin is the largest organ of humans. Overexposure to ultraviolet (UV) is the primary environmental factor that causes skin damage. The compound, (-)-loliode, isolated from the brown seaweed Sargassum horneri , showed strong antioxidant and anti-inflammatory activities in in vitro and in vivo models. To further explore the potential of (-)-loliode in cosmetics, in the present study, we investigated the photoprotective effect of (-)-loliode in vitro in skin cells and in vivo in zebrafish. The results indicated that (-)-loliode significantly reduced intracellular reactive oxygen species (ROS) level, improved cell viability, and suppressed apoptosis of UVB-irradiated human keratinocytes. In addition, (-)-loliode remarkably attenuated oxidative damage, improved collagen synthesis, and inhibited matrix metalloproteinases expression in UVB-irradiated human dermal fibroblasts. Furthermore, the in vivo test demonstrated that (-)-loliode effectively and dose-dependently suppressed UVB-induced zebrafish damage displayed in decreasing the levels of ROS, nitric oxide, lipid peroxidation, and cell death in UVB-irradiated zebrafish. These results indicate that (-)-loliode possesses strong photoprotective activities and suggest (-)-loliode may an ideal ingredient in the pharmaceutical and cosmeceutical industries. |
