Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study.

Autor:	Hummel T; Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, 01307 Dresden, Germany., Haehner A; Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, 01307 Dresden, Germany., Thaploo D; Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, 01307 Dresden, Germany., Georgiopoulos C; Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, 01307 Dresden, Germany.; Department of Radiology in Linköping, Linköping University, 58183 Linköping, Sweden.; Department of Health, Medicine and Caring Sciences, Linköping University, 58183 Linköping, Sweden., Falkenburger B; Department of Neurology, TU Dresden, 01307 Dresden, Germany., Whitcroft K; UCL Ear Institute, UCL, 332 Grays Inn Rd., London WC1X 8EE, UK.
Jazyk:	angličtina
Zdroj:	Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2021 Nov 01; Vol. 57 (11). Date of Electronic Publication: 2021 Nov 01.
DOI:	10.3390/medicina57111183
Abstrakt:	Loss of sense of smell is a well-known non-motor symptom of Parkinson's disease (PD). Here, we present insight into the association between PD advancement and equivalents of smell loss in olfactory-eloquent brain areas, such as the posterior cortex and orbitofrontal cortex. Twelve PD patients in different Hoehn and Yahr stages and 12 healthy normosmic individuals were examined with diffusion tensor imaging. Tract-based spatial statistics were used to analyze microstructural changes in white matter adjacent to the bilateral posterior and orbitofrontal cortex. Axial diffusivity, mean diffusivity, and radial diffusivity were significantly higher in olfactory ROIs in advanced PD patients. The results of this preliminary study indicate that PD advancement is associated with progressive neurodegeneration in olfactory-related brain areas.
Databáze:	MEDLINE
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