| Autor: |
Ass'ad NA; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA., Shore X; Department of Family and Community Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA., Myers O; Department of Family and Community Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA., Camacho AR; College of Nursing, University of New Mexico-Health Sciences Center, Albuquerque, NM 87131, USA., Jacquez Q; College of Nursing, University of New Mexico-Health Sciences Center, Albuquerque, NM 87131, USA., Pollard C; Miners' Colfax Medical Center, 203 Hospital Drive, Raton, NM 87740, USA., Cook LS; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.; Department of Epidemiology, School of Public Health, University of Colorado-Anschutz, Arora, CO 80045, USA., Leng S; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA., Page K; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA., Sood A; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.; Miners' Colfax Medical Center, 203 Hospital Drive, Raton, NM 87740, USA., Zychowski KE; College of Nursing, University of New Mexico-Health Sciences Center, Albuquerque, NM 87131, USA. |
| Abstrakt: |
The United States has a rich history of mining including uranium (U)-mining, coal mining, and other metal mining. Cardiovascular diseases (CVD) are largely understudied in miners and recent literature suggests that when compared to non-U miners, U-miners are more likely to report CVD. However, the molecular basis for this phenomenon is currently unknown. In this pilot study, a New Mexico (NM)-based occupational cohort of current and former miners ( n = 44) were recruited via a mobile screening clinic for miners. Serum- and endothelial-based endpoints were used to assess circulating inflammatory potential relevant to CVD. Non-U miners reported significantly fewer pack years of smoking than U-miners. Circulating biomarkers of interest revealed that U-miners had significantly greater serum amyloid A (SAA), soluble intercellular adhesion molecule 1 (ICAM-1, ng/mL), soluble vascular cell adhesion molecule 1 (VCAM-1, ng/mL), and VCAM-1 mRNA expression, as determined by the serum cumulative inflammatory potential (SCIP) assay, an endothelial-based assay. Even after adjusting for various covariates, including age, multivariable analysis determined that U-miners had significantly upregulated VCAM-1 mRNA. In conclusion, VCAM-1 may be an important biomarker and possible contributor of CVD in U-miners. Further research to explore this mechanism may be warranted. |
