Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression.
| Autor: | Tolg C; London Regional Cancer Program, Lawson Health Research Institute, London, ON N6A 5W9, Canada., Messam BJ; Department Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada., McCarthy JB; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Nelson AC; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA., Turley EA; London Regional Cancer Program, Lawson Health Research Institute, Department Oncology, Biochemistry and Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada. |
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| Jazyk: | angličtina |
| Zdroj: | Biomolecules [Biomolecules] 2021 Oct 20; Vol. 11 (11). Date of Electronic Publication: 2021 Oct 20. |
| DOI: | 10.3390/biom11111551 |
| Abstrakt: | Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression. |
| Databáze: | MEDLINE |
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